Wyniki wyszukiwania - Biblioteka Nauki

1

Celiaklia

100%

Motybel-lwańczuk E. , Zińczuk J. , Matowicka-Karna J.

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2018

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tom nr 4

32--36

PL

Celiakia, choroba trzewna, jest najczęściej występującą chorobą o podłożu autoimmunologicznym, w której czynnikiem indukującym procesy chorobowe jest gluten. Dotychczas choroba była kojarzona z okresem wieku dziecięcego, z remisją kliniczną choroby w czasie dojrzewania. Obecnie około 60% nowych przypadków jest rozpoznawanych u osób dorosłych, w tym nawet 20% wykrywanych przypadków dotyczy pacjentów po 60 r.ż. Zdecydowanie częściej na celiakię chorują kobiety, stanowiąc ok. 70% wszystkich chorych. W ostatnich latach zaobserwowano także zmianę przebiegu klinicznego choroby na postać nietypową, z przewagą objawów spoza układu pokarmowego. Prawidłowe postawienie diagnozy oraz szybkie wprowadzenie leczenia wpływają na stan zdrowia i dalsze życie chorego.

EN

Coeliac disease is the most common autoimmune disease in which gluten is the factor inducing disease processes. So far, the disease has been associated with childhood, with its clinical remission during adolescence. Currently, about 60% of new cases are being diagnosed in adults, including up to 20% of detected cases in patients over 60 years of age. Women suffer from coeliac disease more often, accounting for about 70% of all patients. ln recent years, a change in the clinical course of the disease has been also observed - to its atypical or oligosymptomatic form, with the prevalence of non-gastrointestinal symptoms. Correct diagnosis and the rapid introduction of treatment affect a patient's health and their further life.

2

Znaczenie diagnostyczne wybranych autoprzeciwciał w chorobach układowych tkanki łącznej

100%

Zińczuk J. , Motybel-lwańczuk E. , Matowicka-Karna J.

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2018

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tom nr 4

26--31

PL

Choroby autoimmunologiczne należą do chorób przewlekłych o zróżnicowanej, często niewyjaśnionej etiologii o podłożu autoimmunizacyjnym i powstają wskutek nieprawidłowej odpowiedzi immunologicznej skierowanej przeciwko własnym antygenom. Antygeny stymulują wytwarzanie autoprzeciwciał, które wiążąc się z nimi, prowadzą do uszkodzenia komórek i tkanek organizmu. W efekcie dochodzi do rozwoju szeregu chorób o szerokim spektrum objawów, których podstawą rozpoznania jest stwierdzenie w surowicy chorego przeciwciał typowych dla danej jednostki. Przeciwciała te mają dużą wartość diagnostyczną i prognostyczną i pozwalają wnioskować o ciężkości przebiegu choroby.

EN

Autoimmune diseases belong to the group of chronic diseases with diversified, often unexplained, autoimmune aetiology and develop as a result of an abnormal immune response against the body's own antigens. The antigens stimulate the production of autoantibodies, which bind with them and lead to the damage of the cells and tissues of the body. The result is the development of a number of diseases of a broad spectrum of symptoms. ln order to diagnose these diseases, it is necessary to determine antibodies specific to a given disease in a patient's serum. These antibodies have a high diagnostic and prognostic value and enable to conclude on the severity of the course of the disease.

3

Glucagonoma as a rare case of neuroendocrine tumor of the pancreas: a case report

88%

Zińczuk J. , Lewoniewska S. , Zaręba K. , Pryczynicz A. , Guzińska-Ustymowicz K.

Progress in Health Sciences

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2019

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tom 1

169-173

EN

Introduction: Glucagonoma is a rare neuroendocrine tumor with characteristic features such as the presence of the glucagon-producing tumor, diabetes, and necrolytic migratory erythema. Case presentation: the 60-year-old patient was admitted to hospital with periodic pain in the right and middle upper abdominal appearing after eating. Laboratory tests presented a high glucose level and anemia. Tumor of the body and tail of the pancreas passing the organ pouch has been found during the surgery. Diagnosis of glucagonoma was confirmed in histopathological examination in immunohistochemical stainings: a positive reaction was observed with chromogranin, synaptophysin and CEA. The proliferative activity of Ki-67 was less than 1%. Staining for glucagon also was positive so confirmed the presence of neuroendocrine tumor - glucagonoma. Conclusions: Glucagonoma sometimes may occur without characteristic features which may cause delayed diagnosis. Early diagnosis of glucagonoma is important because it increases the chances of successful recovery.

4

Spigelian hernia: a case report

75%

Martyniuk M. , Ustymowicz W. , Zińczuk J. , Pryczynicz A. , Guzińska-Ustymowicz K. , Kędra B. , Zaręba K.

Progress in Health Sciences

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2019

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tom 2

53-56

EN

Spigelian hernias constitute a minute fraction of all abdominal hernias. In this monography, we present a case report of this relatively seldom seen phenomenon which some general surgeons never get to see during their medical career.

5

Physiotherapy in women after breast cancer treatment – review

75%

Skutnik K. , Ustymowicz W. , Zubrewicz K. , Zińczuk J. , Kamińska D. , Pryczynicz A.

Progress in Health Sciences

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2019

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tom 1

162-168

EN

Introduction: Breast cancer is the most common malignant tumor in women in the Polish region. Surgery is a basic method of breast cancer treatment. Surgery often carries a lot of unwanted changes as follows: limitation of mobility in the shoulder joint on the operated side, secondary lymphoedema, post mastectomy pain syndrome (PMPS), reduction of muscle strength or disorders in body posture. Therefore, the implementation of physiotherapeutic activities that are designed to prevent and eliminate postoperative complications seems very important. The main aim of this work was to present physiotherapeutic management in women after mastectomy based on the analysis of available literature. The physiotherapeutic process can be divided into three periods: early hospital, early ambulatory and the late ambulatory period. In the first period, active slow exercises, self-support of the upper limb on the operated side and breathing exercises on the thoracic track are used to prevent circulatory disorders, pulmonary complications, and edema. The early ambulatory period includes corrective exercises, general improvement exercises, stretching and learning of automatic massage of the upper limb of the operated side. The last period should be enriched by recreational methods of physical activity such as swimming, cycling or Nordic walking to maintain physical fitness, proper mobility of the shoulder girdle and improve the patient's psychophysical state. It is very important the patient regular continues the rehabilitation program after curing of breast cancer as well. In the case of secondary lymphoedema of the upper limb, comprehensive rehabilitation physiotherapy is used, consisting of manual lymphatic drainage, healing exercises, compression therapy, and skin care. Conclusions: Physiotherapy in women after breast cancer surgery is a complex and long-term process. Physiotherapeutic methods are effective in treating complications after surgery of breast cancer surgery. It is necessary to constantly update the physio-therapy knowledge in women after breast cancer surgery.

6

Immunohistochemical Fascin-1 expression correlate with lymph node and distant metastases in pancreatic ductal adenocarcinoma

63%

Pryczynicz A. , Nizioł M. , Miniewska K. , Kamińska D. , Kuczyńska P. , Zińczuk J. , Zaręba K. , Guzińska-Ustymowicz K.

Progress in Health Sciences

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2018

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tom 8(2)

124-130

EN

Introduction: Pancreatic cancer is characterized by its aggressiveness and poor prognosis. Furthermore, mortality is one of the highest among all types of cancers. It has been observed that the expression of Fascin-1 (the actin-bundling protein which enables the motility of cells) is higher in cancer cells and is correlated with invasiveness and metastasis. Purpose: To investigate the expression of Fascin-1 in histopathological specimens from patients treated for pancreatic cancer and its relationship with histopathological parameters. Materials and methods: The study was performed on a group of 52 patients diagnosed with pancreatic cancer in the Medical University of Bialystok Clinical Hospital. The expression of Fascin-1 was evaluated in tissue samples using the immunohistochemical method and was rated as “present” or “absent”. The analysis of histopathological parameters was performed in correlation with Fascin-1 expression. Results: Fascin-1 expression was observed in the cytoplasm of cancer cells in 42/52 cases (80.8%). Fascin-1 expression occurred more frequently among patients with lymph node metastases (92.6%) than without this type of metastases (68%) (p=0.024). Likewise, the expression of the investigated protein was observed more often with the presence of distant metastases (100%) than without those metastases (74.4%) (p=0.043). There were no statistically significant differences about age, sex, histological type of cancer, grade of histological differentiation, desmoplasia, inflammatory infiltration, foci of hemorrhage, necrosis, and MVD. Conclusion: The expression of Fasicn-1 is correlated with the presence of metastases and can be a useful marker of pancreatic cancer involvement.

7

Symptoms of colorectal cancer contributes to its localization and advancement

63%

Nizioł M. , Kostrzewska B. , Kamińska D. , Domurat M. , Zińczuk J. , Misiura M. , Guzińska-Ustymowicz K. , Pryczynicz A.

Progress in Health Sciences

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2019

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tom 1

76-82

EN

Introduction: Colorectal cancer is one of the most common cancers occurring in Poland. Unfortunately, this cancer is most often diagnosed at the time of great advancement. This is caused by the appearance of specific symptoms only in the late stages of cancer. Also, such low detection of early stages of adenocarcinoma may be caused by disregarding of slight symptoms. Purpose: To analyse symptoms in patients with colorectal cancer and correlate with chosen clinical-pathological parameters. Materials and methods: The study group consisted of 46 patients diagnosed with colorectal cancer. Information on symptoms associated with cancer (subjective and objective) have been selected from patients' medical history. The presence of these symptoms was correlated with the age and sex of patients, tumor location, histological type of cancer, grade of histological malignancy (G), stage of tumor (T stage), presence of lymph node metastases and distant metastases. Results: It has been shown that the presence of pain complaints described by the patient are associated with the occurrence of cancer in the colon. The painfulness and pathological resistance diagnosed by the physician are more often associated with cancer located in the colon. In the case of tumors located in the rectum, faecal admixtures appear more frequently. It has also been shown that the presence of admixtures of blood and mucus in the stool is associated with more advanced local tumors, infiltrating pericolorectal tissues (T3 + T4). Conclusions: Familiarity with clinical symptoms of colorectal cancer could make patients more sensitive to more often screening for cancer. Analysis of these symptoms could indicate to the physician the location or stage of the cancer.

8

Expression of EpCAM protein in gastric cancer cells may contribute to its histogenesis

51%

Nizioł M. , Kuczyńska P. , Misiura M. , Zińczuk J. , Zaręba K. , Ustymowicz W. , Ćwiklińska-Dworakowska M. , Baszun M. , Jelski S. , Guzińska-Ustymowicz K. , Pryczynicz A.

Progress in Health Sciences

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2018

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tom 8(1)

74-79

EN

Introduction: EpCAM protein belongs to adhesion molecules of epithelial cells. It mediates in the homophile adhesion cell-cell reactions. EpCAM protein expression can be observed in the majority of healthy normal cells. However, mutations in EpCAM gene may lead to an increased risk of cancer development. The aim of the study was to assess EpCAM protein expression in the correlation with chosen clinical and histological parameters in gastric cancer. Materials and Methods: EpCAM protein expression was evaluated immunohistochemically in 88 patients diagnosed with gastric cancer. Results: An increase in EpCAM protein expression was demonstrated in cancer cells compared to normal gastric mucosa (59.3% cancers with the positive expression of EpCAM protein). The increased EpCAM protein expression was observed in patients with a histological type of adenocarcinoma without a mucinous component than in those with adenocarcinoma with a mucinous component (p=0.028). The higher expression of this protein was observed also in the intestinal type according to the Lauren classification (p=0.037). The expression of the protein was lower in the diffuse type of cancer. Additionally, an increase in EpCAM protein expression was revealed in cancers infiltrating to the blood vessels (p=0.013). Conclusions: A correlation between EpCAM expression and adenocarcinoma without a mucinous component as well as the intestinal type according to the Lauren classification may prove a role of this protein in the histogenesis of gastric cancer. Moreover, its positive expression is related to cancerous cells infiltrating to the blood vessels, which may suggest a role of EpCAM protein in the early stages of gastric cancer metastases.

9

Significance of mucin expression in pancreatic intraepithelial neoplasia (PanIN) – precursor lesions of pancreatic ductal adenocarcinoma (PDAC)

51%

Zińczuk J. , Zaręba K. , Pryczynicz A. , Kuczyńska P. , Boroń Z. , Ustymowicz W. , Maciorkowska M. , Ćwiklińska-Dworakowska M. , Baszun M. , Jelski S. , Guzińska-Ustymowicz K.

Progress in Health Sciences

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2018

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tom 8(1)

63-73

EN

Purpose: To evaluate chosen mucins (mucin 1, 4, 5AC) expression in pancreatic intraepithelial neoplasia, which is a precursor lesion of pancreatic ductal adenocarcinoma. Materials and methods: The study group included 70 patients operated on due to inflammation, cysts and pancreatic ductal adenocarcinoma with pancreatic intraepithelial neoplasia revealed additionally. Mucin 1, 4 and 5AC expression was assessed by immunohistochemical method using polyclonal antibodies. Results: Statistical analysis proved a positive correlation between the expression of mucin 1, 4 and 5AC proteins and the presence and staging of pancreatic intraepithelial neoplasia (p<0.001). Statistically significant correlations were determined between mucin 1, 4 and 5AC and the location of PanIN lesion in the pancreas. Positive correlations were found between mucin 5AC expression and the type of a basic disease (p=0.014). Differences in the expression of MUC 1, 4 and 5AC proteins between healthy pancreatic ducts and various stages of pancreatic intraepithelial neoplasia were statistically significant (p<0.001). Conclusions: Overexpression of mucin 1, 4 and 5AC is related to the presence of pancreatic intraepithelial neoplasia. This suggests that overproduction of mucus is a phenomenon occurring early in the process of carcinogenesis in the pancreas and has its beginning in precancerous lesions of an early stage.