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Activity of selected aromatic amino acids in biological systems

100%

Krzysciak W.

nr 4

Besides the structural function in proteins, aromatic amino acids are precursors of many important biological compounds essential for normal functioning of the human organism. Many of these compounds may be used as markers for identification of specific pathological states. Comprehensive knowledge about the metabolism of aromatic amino acids and mechanisms of action of their metabolites made it possible to develop effective treatments for many disorders. However, it should not be forgotten that in some pathological conditions, these compounds could not only be involved in the pathogenesis of many disease entities but could also be used as an important tool in prediction of many diseases. This paper contains a review of published literature on aromatic amino acids in the context of physiological processes of the human body and chosen social disorders, such as cancers; psychiatric disorders: depression, anxiety states, schizophrenia, bipolar affective disorders; neurodegenerative, and cardiovascular diseases; chronic kidney insufficiency or diabetes.

Generation of reactive oxygen species by a sufficient, insufficient and varicose vein wall

63%

Krzysciak W. , Kozka M.

tom 58

nr 1

Despite numerous theories, the etiology and pathogenesis of primary varicose veins remain unclear. The etiology of chronic venous diseases (CVDs) known as chronic venous insufficiency (CVI) is related to leukocyte trapping. Leukocyte trapping involves trapping of white cells in vessel walls followed by their activation and translocation outside the vessel. Release of reactive oxygen species (ROS) from trapped white cells has been documented. Superoxide dismutase (SOD) directly inhibits the generation of free radicals and compounds that are produced during oxidation by ROS, such as malonyldialdehyde (MDA). The aim of this study was to determine the involvement of free radicals in the etiology of venous changes. The following material was used for the study: fragments of sufficient or insufficient venous system and varices from 31 patients diagnosed with chronic venous disease in the 2nd or 3rd degree, according to clinical state, etiology, anatomy and pathophysiology (CEAP), which were qualified for surgical procedure. The levels of oxidative stress markers strongly correlated with lesions observed by USG in insufficient and varicose veins. In both a higher concentration of MDA was observed, which is a sign of lipid peroxidation. Antioxidative mechanisms, SOD activity and total antioxidative power expressed as FRAP were inversely proportional to MDA concentration. In insufficient and varicose veins both FRAP and SOD activities were significantly lower than in normal veins. The severity of clinical changes was inversely dependent on the efficiency of scavenging of ROS, which additionally proves the participation of free radicals in pathogenesis of CVDs.

The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide

63%

Papiez M. A. , Krzysciak W.

nr 4

Activities of glutathione peroxidase and catalase in organs from vanadium-treated rats

51%

Krosniak M. , Krzysciak W. , Kareta A. , Grybos R.

2009

tom 51

39-48

Salivary oxidative status in patients with oral lichen planus

32%

Darczuk D. , Krzysciak W. , Vyhouskaya P. , Kesek B. , Galecka-Wanatowicz D. , Lipska W. , Kaczmarzyk T. , Gluch-Lutwin M. , Mordyl B. , Chomyszyn-Gajewska M.

nr 6

Antimicrobiological effects of extracts from Cornelian-cherry (Cornus mas L.) is related to the flavonoids contents and blood antioxidant properties

32%

Krosniak M. , Francik R. , Krzysciak W. , Berkoz M. , Krzysciak P. , Bystrowska B. , Ochonska D. , Kryczyk J.

tom 61

nr Suppl.1

Alterations in glutathione peroxidase and superoxide dismutase activities in plasma and saliva in relation to disease activity in patients with Crohn's disease

32%

Szczeklik K. , Krzysciak W. , Domagala-Rodacka R. , Mach P. , Darczuk D. , Cibor D. , Pytko-Polonczyk J. , Rodacki T. , Owczarek D.

nr 5