Wyniki wyszukiwania - Biblioteka Nauki

1

Od nostalgii do PTSD

100%

Korolczuk A. , Gołębiowski A. , Tomko-Gwoździewicz M.

Zeszyty Naukowe / Wyższa Szkoła Oficerska Wojsk Lądowych im. gen. T. Kościuszki

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2009

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tom Nr 3

115-124

PL

Udział w konflikcie zbrojnym jest prawdopodobnie najbardziej traumatycznym doświadczeniem człowieka. Historia naszej cywilizacji to w znacznej mierze historia konfliktów zbrojnych. Biorący w nich udział Sołnierze - głównie młodzi ludzie - reagowali na wojnę w sposób będący typową, normalną reakcją na nienormalną rzeczywistość. Reakcje te nazywano między innymi nostalgią, tęsknotą za domem, nerwicą wojenną, zespołem stresu pourazowego (PTSD-posttraumatic stress disorder). Stosowane określenia miały uwarunkowania kulturowe, polityczne, odzwierciedlały także stan wiedzy medycznej. Proponowane formy pomocy medycznej miały na celu pomóc żołnierzem wrócić do jednostek. Wydaje się, że właściwy dobór do służby wojskowej, szkolenie oparte na rozwijaniu wyobraźni, innowacyjności mogą w znacznym stopniu ograniczyć następstwa traumatycznych doświadczeń wojennych. Analizując wnioski z konfliktów, łącząc je z nowymi formami szkolenia i pomocy żołnierzom, możemy skuteczniej radzić sobie z następstwami traumy wojennej.

EN

Participation in an armed conflict is probably the most traumatic experience for a person. The history of our civilization is largely the history of armed conflicts. Soldiers who take part in them - mainly young people – responded to war with a typical, normal reaction to an abnormal situation. These reactions were named nostalgia, homesickness, war neurosis or PTSD. The terms used were both culturally and politically conditioned and they also reflected the state of medical knowledge. Medical assistance offered was to help soldiers return to their units. It appears that the appropriate selection for military service, training based on the development of imagination and innovation can significantly reduce the consequences of traumatic experiences of war. When examining the lessons learned from these conflicts, combining them with new forms of training and supporting troops, one can effectively deal with the aftermath of war trauma.

2

The role of PPAR gamma agonists - rosiglitazone and 15-deoxy-delta12,14-prostaglandin J2 in experimental cyclosporine a hepatotoxicity

88%

Sikora-Wiorkowska A. , Smolen A. , Czechowska G. , Wiorkowski K. , Korolczuk A.

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tom 70

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nr 6

3

Effects of peroxisome proliferator-activated receptors-gamma ligands on dextran sodium sulphate-induced colitis in rats

75%

Celinski K. , Dworzanski T. , Korolczuk A. , Piasecki R. , Slomka M. , Madro A. , Fornal R.

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nr 3

EN

Recent studies indicate the involvement of peroxisone proliferator-activated receptor- (PPAR-) in the inflammatory reaction. The exact mechanism of PPAR- action has not been elucidated. It is supposed that PPAR- regulates transcription of genes responsible for encoding cytokines involved in the inflammatory response. The latest studies, carried out to explain the pathogenesis of non-specific colitis, confirm beneficial effects of PPAR- agonists on attenuation of colon inflammation. The aim of the present study was to assess the effects of nuclear PPAR- activity on the course of experimental acute colitis induced by intragastric administration of dextran sodium sulphate (DSS) using the PPAR- agonist rosiglitazone and the antagonist BADGE in rats. Colitis in Wistar rats was induced by 1.5% DSS administered in drinking water for 8 days. Animals with induced colitis received rosiglitazone, bisphenol A diglycidyl ether (BADGE) or both substances. After decapitation, colons were macroscopically and histopathologically evaluated. Levels of interleukin-1ß (IL-1ß), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor- (TNF-) and myeloperoxidase (MPO) were determined in serum and colon homogenates using ELISA. In rats with experimentally induced colitis receiving rosiglitazone, the inflammatory reaction was found to be markedly limited; ulceration, oedema and infiltration activity were reduced. The activated PPAR- inhibit the expression of proinflammatory factors, such as IL-6, TNF-, and neutrophil chemotaxis, which was evidenced by MPO reduction in serum and colon homogenates mediated by rosiglitazone. The positive effects of rosiglitazone on expression of IL-10 were also demonstrated. During the short period of observation, BADGE did not increase histopathological inflammatory markers.

4

Comparison of the anti-inflammatory and therapeutic actions of PPAR-gamma agonists rosiglitazone and troglitazone in experimental colitis

75%

Celinski K. , Dworzanski T. , Fornal R. , Korolczuk A. , Madro A. , Slomka M.

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tom 63

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nr 6

5

The effect of the angiotensin II receptor, type 1 receptor antagonists, losartan and telmisartan, on thioacetamide-induced liver fibrosis in rats

63%

Czechowska G. , Celinski K. , Korolczuk A. , Wojcicka G. , Dudka J. , Bojarska A. , Madro A. , Brzozowski T.

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2016

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tom 67

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nr 4