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EN
The emergence and spreading of new exotic viral diseases is most probably caused by the destruction of the tropical biosphere and, furthermore, due to the genetic variation of virus virulence, tropism and adaptation to other species (breaking the species barrier). An efficient control of such viral infections requires constant collaboration of medical and veterinary scientists. Some new presented data concern: identification of interferon-producing cells; RNA vaccine on flavivirus model; training viruses to attack cancer; neuraminidase inhibitors - efficient anti-influenza drugs; Nipah virus of Malaysian epidemic; neurovirulence of porcine reproductive and respiratory syndrome virus; malignant catarrhal fever in pigs caused by ovine herpesvirus 0-2.
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tom 15
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nr 11
RU
Поросята пулавской расы оказались более восприимчивы на внутримозговое заражение вирусом тешенской болезни чем поросята расы белой свислоухой. Разница восприимчивости не является статистически существенной но близка к таковой.
EN
Piglings of the Puławy breed proved to be more susceptible to the intracerebral infection with the virus of Teschen disease than piglings of the breed White, large ears hangin down. The difference in the susceptibility is not statistically essential but very close to that to regard it as essential.
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tom 49
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nr 05
195-198
EN
Organ culture and reverse genetics for a newly identified human rhinovirus C will facilitate studies of its biology and receptor identification. Fundamental importance of commensal gut microbiota in viral infections. Succesful transmission of retroviruses. Promoting enteroviral (poliovirus and reovirus) replication and systemic pathogenesis. Intravenously delivered oncolytic JX-594 poxvirus selectively infects, replicates and expresses transgene products in metastasized cancer tissue. Adcetris combaining a synthetic poison vedotin with an antibody that targets CD30 found on many lymphoma cells received marketing approval. Escalation of T follicular helper cell responses by late interleukin-6 controls a chronic viral infection.
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nr 05
EN
A newly emerged H7N9 influenza virus isolated from poultry and humans in China. Its nonpathogenic nature in poultry enables avian H7N9 virus replicate silently in avian species, transmit to humans and become more virulent and transmissible in the human population. Eritoran, a potent, well tolerated, synthetic TLR4 antagonist blocks influenza-induced lethality in mice, as well as lung pathology, clinical symptoms and decreases viral titers. It prevents mortality when administrered up to 6 days after infection of mice. Isolation of two giant amoeba viruses without morphological or genomic resemblance to any previously defined virus families. Different roles of type 1 interferons in acute and chronic viral infections. Microbial colonization influences early B-cell development in the gut. BACH2, the key regulator stabilizes Treg-mediated immune homeostasis. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
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