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2 Acta Poloniae Pharmaceutica - Drug Research

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THE EFFECTS OF SULFUR-CONTAINING COMPOUNDS ON REDOX STATUS IN HOMOCYSTEINE-TREATED RATS

100%

Sobot T. S. , Zivkovic V. I. , Srejovic I. M. , Jeremic J. N. , Nikolic Turnic T. R. , Ponorac N. D. , Petkovic A. M. , Jakovljevic V. L. , Djuric D. M.

Acta Poloniae Pharmaceutica - Drug Research

2019

tom 76

nr 1

147-157

There is growing interest in the activity of sulfur-containing compounds on redox balance in physiological and pathological conditions, considering that some of these compounds have not only antioxidative but also pro-oxidative activities. Aim of this study was to assess possible differences in the effects of various sulfur-containing compounds on redox balance of cardiovascular system in its physiological state and in the early onset of hyperhomocysteinemia. This experimental study divided Wistar albino rats into two groups: saline-treated (control) and DL-homocysteine-treated (experimental group). Rats from experimental group were subjected to subchronic subcutaneous administration of DL-homocysteine at dose of 0.45 μmol/g body weight twice a day for 2 weeks. At the end of this period, rats were sacrificed, and blood samples were collected to be analysed for homocysteine concentration and systemic oxidative stress. Isolated rat hearts were excised and attached to the Langendorff apparatus. To assess the effects of acute administration of L-methionine, L-cysteine, N-acetylcysteine, and sodium hydrogen sulfide, the hearts were perfused individually with each of the mentioned substances at same single dose of 0.5 mmol/l for 5 min. In collected samples of coronary venous effluent oxidative stress biomarkers were determined using spectrophotometry. Total homocysteine level was significantly higher in the experimental group than in the control group, and the effects of applied sulfur-containing compounds were significantly different in experimental and control groups. DL-homocysteine induced considerable changes in functioning of cardiovascular system even before an increase in plasma homocysteine values, and action of sulfur-containing compounds varied depending on the presence of homocysteine.

BIOLOGICAL ACTIVITIES OF DIFFERENT EXTRACTS FROM ALLIUM URSINUM LEAVES

80%

Tomovic M. T. , Krivokapic M. Z. , Jakovljevic V. L. , Sovrlic M. M. , Bradic J. V. , Petkovic A. M. , Radojevic I. D. , Brankovic S. R. , Comic L. R. , Andjic M. M. , Kocovic A. G.

Acta Poloniae Pharmaceutica - Drug Research

2020

tom 77

nr 1

121-129

The aim of our study was to evaluate and compare antioxidant and antimicrobial activity of aqueous, methanol and chloroform extracts of leaves of Allium ursinum (A. ursinum). Total phenol (TPC) and flavonoid (TFC) content in extracts and antioxidant activity using DPPH (1,1- diphenyl-2-picrylhydrazyl) assay were determined spectrophotometrically. In vitro antimicrobial activity was tested by microdilution method. The highest TPC and TFC were observed for chloroform extract. The extracts showed different degrees of antimicrobial activity. The intensity of antimicrobial action varied depending on the group of microorganism and the type of extracts. Our results demonstrated rational basis for the traditional uses of A. ursinum in alleviation of oxidative stress and against various pathogenic microorganisms.