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1 Journal of Applied Genetics

1 1996

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Association of chosen microsatellite markers on chromosomes 10, 11p and 14q with IDDM susceptibility in the population of midwestern Poland

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Jungerman M. , Fichna P.

Journal of Applied Genetics

1996

tom 37

nr 2

217-228

In search for new markers of insulin-dependent diabetics (IDDM) susceptibility we studied the CATT tetranucleotide repeat in intron 1 of tyrosine hydroxylase (TH) gene on chromosome 11p, the CA repeat at T-cell receptor alpha chain (TCRA) locus on chromosome 14q region containing glutamic acid decarboxylase (GAD2) gene.Alleles at these microsatellite loci were indentified in a population of diabetic children and unrelated healthy controlos originationg from Wielkopolska, a midwestern region of Poland.We found significant association of certain alleles at TH, TCRA and D10S211 loci with diabetes in the population under study.On the contrary, none of the alleles at D10S213 locus was associated with the disease.Our findings indicate that typing of microsatellite markers may represent useful additional tool for identifying individuals at high risk of developing IDDM.Regarding loci on chromosome 10 our data and data publishing by other autors may suggest the existence of two separate regions of associatin with IDDM susceptibility on this chromosome.