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3 Acta Biochimica Polonica

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Interaction of class A G protein-coupled receptors with G protein.

100%

Ślusarz R. , Ciarkowski J.

2004

tom 51

nr 1

129-136

A model for interaction of class A G protein-coupled receptor with the G protein Gα subunit is proposed using the rhodopsin-transducin (RD/Gt) prototype. The model combines the resolved interactions/distances, essential in the active RD*/Gt system, with the structure of Gtα C-terminal peptide bound to RD* while stabilizing it. Assuming the interactions involve conserved parts of the partners, the model specifies the conserved Helix 2 non-polar X- - -X, Helix 3 DRY and Helix 7/8 NP- -Y- - F RD* motifs interacting with the Gtα C-terminal peptide, in compliance with the structure of the latter. A concomitant role of Gtα and Gtγ>C-termini in stabilizing RD* could possibly be resolved assuming a receptor dimer as requisite for G protein activation.

Molecular docking-based test for affinities of two ligands toward vasopressin and oxytocin receptors.

70%

Ślusarz R. , Kaźmierkiewicz R. , Giełdoń A. , Lammek B. , Ciarkowski J.

tom 48

nr 1

131-135

Molecular docking simulations are now fast developing area of research. In this work we describe an effective procedure of preparation of the receptor-ligand complexes. The amino-acid residues involved in ligand binding were identified and described.

Signal transmission via G protein-coupled receptors in the light of rhodopsin structure determination.

70%

Ciarkowski J. , Drabik P. , Giełdoń A. , Kaźmierkiewicz R. , Ślusarz R.

tom 48

nr 4

1203-1207

G protein-coupled receptors (GPCRs) transducing diverse external signals to cells via activation of heterotrimeric GTP-binding (G) proteins, estimated to mediate actions of 60% of drugs, had been resistant to structure determination until summer 2000. The first atomic-resolution experimental structure of a GPCR, that of dark (inactive) rhodopsin, thus provides a trustworthy 3D prototype for antagonist-bound forms of this huge family of proteins. In this work, our former theoretical GPCR models are evaluated against the new experimental template. Subsequently, a working hypothesis regarding the signal transduction mechanism by GPCRs is presented.