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Entrapment vectors - how to capture a functional transposable element

100%

Solyga A. , Bartosik D.

Polish Journal of Microbiology

2004

tom 53

nr 3

Transposable elements (i.e. insertion sequences and transposons) are components of nearly all bacterial genomes. The majority of these elements have been identified as a result of various sequencing projects. However, in most cases, their activity was not experimentally confirmed. For this reason several strategies have been developed that allow direct cloning and identification of functional transposable elements. Most of the methods are based on the ability of transposable elements to inactivate or activate particular genes by insertion. In this review we describe and critically discuss different cloning strategies that employ various entrapment vectors, carrying (i) conditionally lethal genes, (ii) antibiotic selection cartridges, (iii) promoter-less genes or (iv) suicide replicons. These tools, besides facilitating the identification of new transposable elements, also enable the investigation of various DNA rearrangement mutations, which are related to the transposition process.

Mitochondria and aging: innocent bystanders or guilty parties?

80%

Tonska K. , Solyga A. , Bartnik E.

Journal of Applied Genetics

2009

tom 50

nr 1

55-62

There are many theories of aging and a number of them encompass the role of mitochondria in this process. Mitochondrial DNA mutations and deletions have been shown to accumulate in many tissues in mammals during aging. However, there is little evidence that these mutations could affect the functioning of aging tissues.

Grey goo: yet another menace? Nanotechnology in cosmetics - application and safety

80%

Starzyk E. , Frydrych A. , Solyga A.

Towaroznawcze Problemy Jakości. Polskie Towarzystwo Towaroznawcze

2008

nr 2

41-51