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1
Content available remote Relamorelin and other ghrelin receptor agonists - future options for gastroparesis, functional dyspepsia and PPI-resistant non-erosive reflux disease
100%
Zatorski H. , Mosinska P. , Storr M. , Fichna J.
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nr 6
2
Content available remote Modulation of the endocannabinoid system by the fatty acid amide hydrolase, monoacylglycerol and diacylglycerol lipase inhibitors as an attractive target for secretory diarrhoea therapy
100%
Wasilewski A. , Misicka A. , Sacharczuk M. , Fichna J.
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nr 4
3
Content available Measurement of Silver Nanolayer Absorption by the Body in an in Vivo Model of Inflammatory Gastrointestinal Diseases
100%
Siczek K. , Pawlak W. , Zatorski H. , Fichna J.
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tom Vol. 23, nr 1
133--142
EN
Layers of silver particles are used in the studies on pathophysiology and treatment of diseases, both in pre-clinical and clinical conditions. Silver layers can be formed using different techniques and on different substrates. Deposition by magnetron sputtering on glass beads was used in this study. Silver absorption by the body was estimated by calculating the difference in thickness of the silver nanolayer deposited on a bead and measured before and after application of the bead in an animal model of gastrointestinal inflammation. Recommendations for the minimal thickness of silver nanolayer deposited on glass beads were worked out for further studies.
4
Content available remote Effect of cerebral ventricles perfusion with morphiceptin and met-enkephalin on trigemino-hypoglossal reflex in rats
100%
Zubrzycka M. , Fichna J. , Janecka A.
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tom 53
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nr 4,2
EN
Opioids administered by intracerebroventricular injections produce analgesic responses in rats. The present study was undertaken to investigate the effects of a highly selective m-opioid receptor ligand morphiceptin on trigemino-hypoglossal reflex in rats. The analgesic effect of morphiceptin was compared with another opioid peptide, Met-enkephalin. With the experimental settings used in this study, we have demonstrated that both morphiceptin and Met-enkephalin show significant dose-dependent analgesic effects after i.c.v. administration in rats as assayed by trigemino-hypoglossal reflex test. The antinociceptive response to Met-enkephalin was short lasting and was observed 10 to 15 min after i.c.v. perfusion. Morphiceptin had a relatively longer duration of antinociceptive action, the effect was observed 20- 50 min after i.c.v. perfusion. Neither morphiceptin nor Met-enkephalin produced antinociception after peripheral injections. The results of the present study indicate that both tested peptides act at µ-opioid receptors situated in the central nervous system. They also suggest that µ-opioid receptors present in the central nervous system are an important element of the trigemino-hypoglossal reflex arc. For that reason selective m-opioid receptor ligands, like morphiceptin, inhibit the reflex more significantly.
5
Content available remote The place of tachykinin NK2 receptor antagonists in the treatment diarrhea-predominant irritable bowel syndrome
88%
Szymaszkiewicz A. , Malkiewicz A. , Storr M. , Fichna J. , Zielinska M.
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tom 70
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nr 1
6
Content available remote The effect of long-term melatonin supplementation on psychosomatic disorders in postmenopausal women
75%
Chojnacki C. , Kaczka A. , Gasiorowska A. , Fichna J. , Chojnacki J. , Brzozowski T.
Journal of Physiology and Pharmacology
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2018
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tom 69
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nr 2
7
The impact of extracts from cranberrybush (Viburnum opulus) leaves on the growth of human colon cells
75%
Chojnacka K. , Owczarek K. , Caban M. , Fichna J. , Sosnowska D. , Redzynia M. , Lewandowska U.
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nr S2
8
Content available Sleep disturbance and disease activity in adult patients with inflammatory bowel diseases
75%
Sobolewska-Wlodarczyk A. , Wlodarczyk M. , Banasik J. , Gasiorowska A. , Wisniewska-Jarosinska M. , Fichna J.
Journal of Physiology and Pharmacology
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2018
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tom 69
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nr 3
9
FKRP gene mutations and candidate disease-modifying genes in Polish patients with limb-girdle muscular dystrophy – results of whole exome sequencing study
63%
Macias A. , Fichna J. , Korostynski M. , Piechota M. , Potulska-Chromik A. , Redowicz M. J. , Zekanowski C. , Kaminska A. M. , Kostera-Pruszczyk A.
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nr Suppl.1
EN
INTRODUCTION: Limb-girdle muscular dystrophies (LGMD) are hereditary progressive disorders of skeletal muscles. Currently 33 LGMD types are recognized. For up to 50% of LGMD patients the causal genetic defect remains unknown. There is considerable phenotypic variability, even among patients with identical causal mutation. Mutations in fukutin-related protein (FKRP) gene are responsible for an autosomal recessive type 2 I of LGMD, which is a relatively frequent type of LGMD in Europe. AIM(S): The aim of this work was to assess frequency of LGMD2I in Polish LGMD patients, characterize the pathogenic mutations, clinical phenotype and possible disease modifying genes. METHOD(S): The study involved 85 patients with LGMD diagnosis based on clinical assessment and muscle biopsy. Whole exome sequencing of peripheral blood DNA was performed. Filtering of the identified variants was based on allele frequency, association with Human Phenotype Ontology terms and predicted pathogenicity. Selected variants were confirmed using a direct fluorescence‑based sequencing. RESULTS: Homozygous or compound heterozygous mutations in FKRP gene were found in 7/85 patients. L276I mutation was the most common one – found in 6/7 LGMD2I patients, 3 of them were homozygous. We could observe considerable phenotypic variability. Candidate disease-modifying genes were COL6A3, COL12A1, PLEC, SYNE1. In 2 patients with particularly severe course of the disease, heterozygous mutation in genes involved In glycosylation process was found (LARGE, ISPD, ITGA7). Two patients were found to be heterozygous for mutations in DYSF gene. CONCLUSIONS: LGMD2I is a common type of LGMD in Polish population. The most common mutation in FKRP gene is L276I. Heterozygocity for mutations in other LGMD genes is high in this group of patients. New generation sequencing methods are a valuable tool for identifying causal mutations, but also for finding candidate disease‑modifying genes, which can help to elucidate mechanisms of LGMD.
10
Myofibrillar myopathies in Poland: Clinical, histopathological and genetic studies
63%
Potulska-Chromik A. , Fichna J. , Karolczak J. , Berdynski M. , Miszta P. , Sikorska A. , Redowicz M. J. , Kostera-Pruszczyk A. , Kaminska A.
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nr Suppl.1
EN
INTRODUCTION: Myofibrillar myopathies (MFMs) are hereditary muscle diseases characterized by distinctive histopathology of myofibrillar disintegration and abnormal protein aggregation. Seven genes: DES, CRYAB, MYOT, FLNC, LDB3, BAG3, PLEC encoding proteins associated with Z disc are considered responsible for MFMs. However in about half of patients, the gene defect is still unknown. AIM(S): The aim of this study was to describe the clinical and histopathological features of genetically confirmed MFM. METHOD(S): 13 patients from 4 families with MFM were systematically identified and clinically studied. The families were not known to be related. In all suspected MFM patients (one proband from each family) disintegration of myofibrils and accumulation of degradation products into inclusions containing desmin were detected in muscle biopsy. However differentiation between MFM subtypes on the basis of clinical/ pathological phenotype alone was impossible. Therefore, subtype identification was performed using molecular studies. RESULTS: All patients presented with progressive muscle weakness with distal-proximal distribution in the lower limbs. CK was normal or slightly elevated. Finally three mutations were identified: two in DES: (Q348P) and (A357_E359del) and one in CRYAB (D109A). In two families with desminopathy caused by A357_E359del mutation cardiac arrhythmias was observed (paternal uncle with similar symptoms died due to cardiac arrhythmia). Dilated cardiomyopathy was confirmed by echocardiography in family with CRYAB D109A. In this family respiratory insufficiency as well as early cataract were diagnosed. CONCLUSIONS: Molecular identification of MFM is crucial for final diagnosis. The awareness of MFM type could be life-saving by means of appropriate treatment such as 1) inserting of a pacemaker in case of significant heart conduction defects and arrhythmia or 2) initiation of noninvasive ventilation in case of chronic respiratory failure.
11
Content available remote High activity of the endogenous opioid system and acute but not chronic stress influence experimental colitis development in mice
51%
Zielinska M. , Szymaszkiewicz A. , Salaga M. , Zatorski H. , Wlodarczyk J. , Jacenik D. , Kordek R. , Krajewska W. M. , Misicka A. , Fichna J. , Sacharczuk M.
Journal of Physiology and Pharmacology
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2018
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tom 69
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nr 5
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