The purpose of the study was to investigate the clinical, biochemical, and cardiovascular effects of intrathecal (IT) administration of ketamine HCl in calves. The study was performed on seven Simmental and three Montofon calves, 1.70± 1.16 weeks old, weighing approximately 37 kg, undergoing surgical procedures including femur fracture repair (one case), atresia anus (five cases), prolapsed rectum (one case), suturing on rear limbs (two cases), and urethrostomy (one case). After administering IT ketamine HCl at a dose of 3 mg/kg to all calves, the level and depth of the anaesthesia was checked with a pinprick test. Each animal was monitored by recording heart rate, arterial blood pressure, respiratory rates, and rectal temperature. Furthermore, certain biochemical parameters, blood gases, oxygen-total haemoglobin, and electrolyte levels were measured. All data were statistically evaluated using Minitab 16 software. Anaesthesia occurred in all calves at an average of 5.00 ± 1.41 min (range: 3-7) and continued for an average of 61.4 ± 40 min (range: 55-70). Sufficient anaesthesia was achieved in all animals for the required operations, and no complications occurred with regard to clinical and haemodynamic measurements. We concluded that in calves, which are not deemed suitable for administration of local anaesthetic via IT due to certain side effects, sufficient anaesthesia can be provided with ketamine by the same method for operations performed in the perineal area and hind extremities, and that this could be a good alternative for anaesthesia under field conditions.
The purpose of this study was to perform the clinical, histopathologic and biochemical evaluation of the effects of intraperitoneally (IP) administered dexpanthenol (dxp) on colonic anastomosis healing in rats. The study was conducted on a total of 28 rats divided into four groups comprising seven rats each. Group I was designated as the control group, group II as the dxp group, group III as the anastomosis group, and group IV as the anastomosis + dxp group. The groups were compared in terms of intestinal bursting pressure, adhesion formation, nitric oxide (NO) and malondialdehyde (MDA) levels, total antioxidant capacity (TAC) and total oxidant capacity (TOC) in blood and intestinal homogenates, as well as histopathologic findings. Dxp decreased adhesion formation (6 rats in group III and 4 rats in group IV). Mean bursting pressures were higher in the dxp groups than in the other groups (group II = 254.3 ± 42.1 mmHg, group IV = 109.3 ± 34.5 mmHg). Moreover, there was a remarkable decrease in the levels of NO and MDA and in blood oxidative stress parameters in the dxp groups. The results suggest that dxp increased intestinal bursting pressure by accelerating healing in the anastomosis line and decreased adhesion formation, positively affecting healing. Dexpanthenol, which was found to have positive effects in the experimental rat model, can be introduced into clinical practice.
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