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Odpornosc przeciw zakazeniu wirusem influenzy koni

100%

Purzycka M. , Rozek W. , Zmudzinski J. F.

tom 63

nr 12

1519-1521

Influenza virus plays an important role in respiratory diseases in horses. Equine influenza virus is represented by two different serotypes: H7N7 and H3N8. The strain H7N7 has not been isolated since 1980 and H3N8 circulates in the equine population throughout most of the world. For preventive and prophylactic measures inactivated and subunit vaccines are most commonly used. Contrary to natural infections, traditional vaccines induce neither cytotoxic lymphocytes T nor mucosal antibodies and they do not provide enduring immunity. There is also the difference in the immune response as the natural infection induces IgA, IgGa and IgGb antibodies whereas the traditional vaccines induce IgGc and IgG(T) and no IgA. The low efficacy of the traditional vaccines also depends on an antigenic drift of the surface glycoprotein - hemagglutynin.

Blood dendritic cells in cattle infected with bovine leukemia virus (BLV): isolation and phenotyping

88%

Szczotka M. , Bednarek D. , Kuźmak J. , Kostro K. , Purzycka M.

2012

nr 4

Blood dendritic cells in cattle infected with bovine leukemia virus (BLV): isolation and phenotyping

88%

Szczotka M. , Kuzmak J. , Kostro K. , Bednarek D. , Purzycka M.

nr 4

Dendritic cells (DCs) are most potent antigen presenting cells (APCs) with unique ability to prime effective immune responses. They express higher levels of MHC class II and accesory molecules on their surface, than other professional APCs. The investigations were performed on DCs generated from blood with the use of microbeads magnetically labeled with mouse anti human CD14. Flow cytometry was applied for determination of DCs immunophenotype in healthy and naturally infected with BLV cattle. For immunophenotyping mouse monoclonal antibodies anti bovine: CD11a, CD11b, CD11c, MHC-I and MHC-II were used. Our results demonstrated that dendritic cells infected with BLV expressed very high percentage of determinants: CD11a, CD11b, CD11c, MHC-I and MHC-II class. Leukaemic DCs exhibited DCs morphology and had a phenotype of mature DCs. The expression of gp51 glycoprotein of BLV on leukaemic DCs was detected in flow cytometry investigations.