Wyniki wyszukiwania - Biblioteka Nauki

1

Chromatografia jako operacja jednostkowa w inżynierii procesowej

100%

Antos D.

Inżynieria Chemiczna i Procesowa

|

2004

|

tom T. 25, z. 3/4

1873-1882

PL

Omówiono zastosowanie chromatografii jako metody rozdziału na skalę przemysłową. Wymieniono dwa główne sposoby realizacji procesu . sposób okresowy, realizowany w kolumnie pojedynczej oraz sposób ciągły, realizowany w szeregowym układzie kolumn chromatograficznych jako procesu SMB (symulowany ruch złoża). Omówiono sposoby modelowania i optymalizacji procesu chromatografii, ze szczególnym uwzględnieniem procesu SMB.

EN

In the work general application of chromatography process in an industrial scale has been discussed. The batch process performed in the single chromatographic column as well as the continuous precess realized in the system of columns assambled in series as the SMB process (Simulated Moving Bed) have been mentioned. The modeling and optimization of chromatography taking particularly into consideration the SMB process have been discussed.

2

Use of simulated annealing for optimization of chromatographic separations

63%

Kaczmarski K. , Antos D.

Acta Chromatographica

|

2006

|

tom No. 17

20-45

EN

The effectiveness of a hybrid of simulated annealing (SA) and the simplex algorithm for optimization of a chromatographic separation has been examined. The method has been used to solve optimization problems for separations in batch and continuous chromatographic systems under isocratic and gradient conditions. To verify the robustness of the algorithm a variety of test problems have been solved. Different objective functions have been optimized subject to different optimization constraints for several operating conditions used as decision variables. The effectiveness of the hybrid procedure has been compared with that of a random search algorithm. The hybrid method proved particularly effective for multicondition optimization involving changes of mobile-phase composition. The method is rapid and robust in location of the global optimum. It does not, moreover, require initiation of the calculations with a “feasible point”, i.e. a point for which optimization constraints are met.

3

Competitive adsorption of solute and modifier in a mixed partition/displacement mechanism in reversed-phase liquid chromatography

63%

Poplewska I. , Antos D.

Acta Chromatographica

|

2006

|

tom No. 17

46-71

EN

Competitive adsorption of the solute and the polar component of the mobile phase (the modifier) in reversed-phase liquid chromatography is discussed. Retention properties on surfaces differing in alkyl chain length (RP-18 compared with RP-8e) have been investigated. Typical solvent mixtures were used as mobile phases–methanol–water and acetonitrile–water. Three different types of compound were selected as solutes–two homologous cycloketones, cyclopentanone and cyclohexanone, and phenol. For all these solutes the adsorption mechanism was heterogeneous – the compounds had affinity for the polar uncovered surface and for the alkyl chains. Adsorption of organic solvents on the RP-8e (endcapped) adsorbent was measured and compared with that on RP-18e and RP-18 (non-endcapped) measured in previous studies. The adsorption equilibrium of solvents was strongly affected by the structure of the adsorbent surface and the polarity of the mobile phase. Variation of separation selectivity as a function of surface properties and mobile-phase composition was also investigated, and is discussed. The model of competitive adsorption proposed in our previous study has been used for analysis of the retention behaviour of the solutes and for prediction of non-linear chromatographic band profiles.

4

Zastosowanie gradientu w procesie SMB

63%

Antos D. , Seidel-Morgenstern A.

Inżynieria Chemiczna i Procesowa

|

2001

|

tom T. 22, z. 3B

181--186

PL

W pracy zaproponowano strategię przeprowadzenia gradientu w SMB dla fazy ciekłej bazującą na modelu dynamiki SMB jako układu chromatograficznego. W oparciu o symulacje komputerowe zaprojektowano doświadczalny rozdział mieszaniny cykloketonów - cyklopentanonu i cykloheptanonu na skalę preparatywną. Następnie przeprowadzono odpowiedni cykl doświadczeń i porównano otrzymane wyniki z symulacjami komputerowymi. Dobra zgodność tych symulacji i wyników doświadczenia potwierdziła słuszność zastosowanego modelu.

EN

In this work the strategy of solvent gradient in the SMB process has been developed. A mathematical model of such process dynamics has been proposed and solved numerically. On the basis of computer simulations experimental separation of the cycloketones mixture has been designed. The model predictions were verified by comparison with experimental results.