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2 Acta Biochimica Polonica

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Structure and function of RNA elements present in enteroviral genomes

100%

Dutkiewicz M. , Stachowiak A. , Swiatkowska A. , Ciesiołka J.

Acta Biochimica Polonica

2016

tom 63

nr 4

623-630

Enteroviruses are small RNA(+) viruses that encode one open reading frame flanked by two extensive noncoding regions carrying structural RNA regulatory elements that control replication and translation processes. For a long time the central, coding region was thought to remain single-stranded and its only function was supposed to be as the template for polyprotein synthesis. It turned out, however, that the protein coding region also encodes important RNA structures crucial for the viral life cycle and virus persistence in the host cells. This review considers the RNA structures in enteroviral genomes identified and characterized to date.

Ribozymes of the hepatitis delta virus: Recent findings on their structure, mechanism of catalysis and possible applications.

88%

Ciesiołka J. , Wrzesinski J. , Łęgiewicz M. , Smólska B. , Dutkiewicz M.

Acta Biochimica Polonica

2001

tom 48

nr 2

409-418

Although the delta ribozymes have been studied for more than ten years the most important information concerning their structure and mechanism of catalysis were only obtained very recently. The crystal structure of the genomic delta ribozyme turns out to be an excellent example of the extraordinary properties of RNA molecules to fold into uniquely compact structures. Details of the X-ray structure have greatly stimulated further studies on the folding of the ribozymes into functionally active molecules as well as on the mechanism of RNA catalysis. The ability of the delta ribozymes to carry out general acid-base catalysis by nucleotide side chains has been assumed in two proposed mechanisms of self-cleavage. Recently, considerable progress has been also made in characterizing the catalytic properties of trans-acting ribozyme variants that are potentially attractive tools in the strategy of directed RNA degradation.