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Vasculitis and anaphylactoid shock induced in mice by cell wall extract of the fungus Candida metapsilosis

100%

Tada R. , Yamanaka D. , Nagi-Miura N. , Adachi Y. , Ohno N.

nr 2

To investigate whether cell wall mannan from Candida metapsilosis induces vasculitis similar to that in Kawasaki syndrome and ana-phylactoid shock in mice, we examined the pathogenic effects of C. metapsilosis cell wall extracts. Our results show that intraperitoneal injection of cell wall extracts induced severe coronary arteritis, and intravenous injection induced acute anaphylactoid shock similar to extracts from Candida albicans (C. albicans). Structural analysis of cell wall mannan from C. metapsilosis using NMR spectroscopy showed it to contain only α-mannan, indicating that α-mannan might be contributing to Candida pathogenicity by inducing coronary arteritis and acute shock.

Effect of cyclic hardening on stress relaxation in SUS316HTP under creep-fatigue loading at 700ºC: experiments and simulations nobutada

86%

Ohno N. , Sasaki T. , Shimada T. , Tokuda K. , Yoshida K. , Okumura D.

tom Vol. 56 nr 2

497--510

Cyclic hardening and stress relaxation experiments of SUS316HTP were performed under creep-fatigue loading with tensile strain holding at 700ºC. Experiments revealed that under strain holding, the slow stress-relaxation stage satisfying Norton’s law with slight cyclic hardening followed a rapid stress-relaxation stage that was noticeably affected by cyclic hardening. This suggests that in the slow stress-relaxation stage, inelastic deformation mechanisms different from that of viscoplasticity occurred. Experiments were simulated using a cyclic viscoplastic-creep model in which the inelastic strain-rate was decomposed into viscoplastic and creep components that were affected differently by cyclic hardening. The simulation accurately reproduced the experiments.