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EN
Morphological lesions in hepatic stellate cells caused by the immunosuppressive doses of dexamethasone were investigated in dogs. The archival samples of liver collected during a surgical biopsy were examined. The samples were fixed in 10% buffered formalin or Carnoy's solution and then stained with routine histochemical methods. The lesions were also investigated under electron microscope. It was demonstrated that the number of stellate cells significantly increased (P = 0.0277), yet the size of cytoplasmic lipid droplets significantly decreased (P = 0.0001). Even though steroid-induced hepatopathy is considered to be a reversible pathology, and the lesions in hepatocytes under the influence of dexamethasone occur in a short period, it was found that hepatic stellate cells proliferated and underwent activation. This resulted in collagen accumulation in the hepatic sinuses. The functional and morphological disturbances in the canine liver in the course of steroid-induced hepatopathy are initially subclinical, but the changes in the structure and function of hepatic stellate cells may become a cause of lesions in the wall of hepatic sinusoidal vessels, which may induce additional functional pathologies unrelated to the damage to hepatocytes.
EN
The aim of the study was to estimate the prevalence and localization of different tumors in the urogenital system in dogs and cats in relation to sex, age and breed of animals. The study was performed on tumors or tissue specimens from tumors of the urinary and genital system obtained during surgery from dogs and cats submitted to the Division of Pathological Anatomy, Department of Clinical Sciences Agricultural University of Warsaw from 1998 to 2005. Most tumors of the urogenital system recognized in the present study derived from dogs (94.20%, 130 cases), and only a few cases were obtained from cats (5.79%). Occurrence and localization of urogenital system tumors in present review is similar to findings reported by other authors. Testicular tumors in males, ovarian lesions in females and urinary bladder tumors in both sexes were most commonly recognized. Older dogs were most often affected, animals with nonmalignant tumors were a bit younger than those with malignant lesions. Any obvious breed predilections were found, but terriers were at increased risk for development of transitional cell carcinoma of the urinary bladder and mixed breed and German shepherd for development of testicular neoplasms.
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