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2 Polish Journal of Chemistry

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Lipoxygenase Inhibiting Steroidal Glycosides and Naphthene Derivatives from Haloxylon salicornicum

100%

Ferheen S. , Ahmed E. , Afza N. , Malik A. , Nawaz S. , Choudhary M.

2005

tom Vol. 79 / nr 9

1469-1476

Allostigmasterol glycosides 1 and 2 and monocyclic naphthene derivatives 3 and 4 have been isolated from methanolic extract of Haloxylon salicornicum and their structures elucidated through spectroscopy. Triacontanoic acid 5, ergosterol peroxide 6 and lupeol 7 were also obtained for the first time from this species. Both 1 and 2 showed moderate lipoxygenase inhibiting activity.

Butyrylcholinesterase Inhibitory C-Glycoside from Symplocos racemosa

84%

Ahmad V. , Zubair M. , Abbasi M. , Kousar F. , Rasheed M. , Rasool N. , Hussain J. , Nawaz S. , Choudhary M.

2006

tom Vol. 80, nr 3

403-407

The re-investigation of the chemical constituents of Symplocos racemosa Roxb. led to the isolation of one new C-glycoside, symcososide (1) along with one known compound beta-sito-glycoside (2). The structure of the new compound was determined by 1D and 2Dhomonuclear and heteronuclearNMRspectroscopy, chemical evidences, and by comparison with the published data of the closely related compounds. The glycoside 1 displayed in vitro inhibitory activity against butyrylcholinesterase (BChE) enzyme with IC50 value of 21.2 š 0.01 miM.