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3 Polish Journal of Surgery

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Role of crossmatch testing when Luminex-SAB is negative in renal transplantation

100%

Jayant K. , Reccia I. , Julie B. M. , Sharma A. , Halawa A.

Polish Journal of Surgery

2018

tom 90(1)

41-46

The human leukocyte antigen (HLA) system plays an important role in the acceptance of renal graft. Long and better graft survival has been reported in patients with HLA-identical siblings and a nonreactive cytotoxicity assay (CDC). New methods of HLA-typing and anti-HLA antibody detection techniques such as flow cytometry, solid-phase immunoassays, or antigen bead assays have further improved the outcomes of renal transplant recipients. In the present review, the explicit details of these methodologies are discussed in detail.

Próby krzyżowe w przeszczepach nerek – ich rola w przypadku ujemnego wyniku testu Luminex-SAB

100%

Jayant K. , Reccia I. , Julie B. M. , Sharma A. , Halawa A.

Polish Journal of Surgery

2018

tom 90(1)

41-46

Ludzki antygen leukocytarny (HLA) odgrywa ważną rolę w akceptacji potencjalnego przeszczepu nerki. Odnotowano dłuższy i lepszej jakości czas przeżycia przeszczepu u pacjentów z rodzeństwem identycznym w HLA i niereaktywnym stopniem testu cytotoksyczności (CDC). Nowe metody typowania HLA i technik wykrywania przeciwciał anty-HLA, takie jak cytometria przepływowa, testy immunologiczne fazy stałej lub testy SAB – Single Antigen Beads, dodatkowo poprawiły wyniki u biorców po przeszczepieniu nerki. W niniejszej pracy szczegółowo omówiono szczegóły informacje dotyczące tej metodologii.

Combination therapy of tadalafil and pentoxifylline in severe erectile dysfunction; a prospective randomized trial

86%

Kumar S. , Roat R. , Agrawal S. , Jayant K. , Mavuduru R. , Kumar S.

Polish Journal of Surgery

2015

tom 87(8)

377-383

The aim of the study was to assess efficacy of Tadalafil alone versus Tadalafil plus Pentoxifylline in the treatment of erectile dysfunction by using self administered IIEF-5 questionnaire. Material and methods. Two hundred and thirty seven patients presenting with ED at andrology OPD were evaluated for ED by a self administered IIEF (International Index of Erectile Function) questionnaire. Patients were systematically randomized by computer generated random table into two groups groups namely, group A: Tadalafil only group, group B: combination of Tadalafil + Pentoxifylline. All the patients were re-assessed by IIEF-5 questionnaire after 8 weeks of medical therapy. Statistical analysis was performed using student’s unpaired t-test, paired t-test, chi square test. pvalue < 0.05 was considered statistically significant. Results. Two hundred and thirty seven patients were included in the present study, in group A: 92 patients (78.6%) showed improvement in their IIEF score after 8 weeks of tadalafil treatment. While in group B, overall 104 patients(86.6%) showed improvement after combination of Tadalafil and Pentoxifylline. There was a statistically significant difference of percentage change in IIEF score was seen in group B (group A 90.7±15.2%, group B 95.6±13.4%; p value – 0.014). We found this difference even more statistically significant in patients with severe ED (group A 72.7±47.2%, group B 132.3±54.3%; p value – 0.000). There was no significant difference in between the two groups with regards to occurrence of side effects. Conclusions. Both tadalafil and combination of Tadalafil + Pentoxifylline improve erectile function in patients of ED. Patients with severe ED showed much significant improvement in erectile function with combination therapy.