The postsegregational killing system of pSM19035 plasmid consists of the proteins Zeta and Epsilon, a toxin and an antidote, respectively. Zeta mutants were isolated with the use of Bacillus subtilis strain with the ζ gene under control of an inducible promoter integrated into the chromosome. Results of mutant analysis point to the amino terminal part of the Zeta protein as being responsible for the toxicity.
the frequency of HLA-DR antigens was studies in 54 patients with mumps meningitis, and in two control groups. The first control group comprised 333 rondomely chosen subjects while the second group was composed of 46 subjects who have passed mumps without meningitis. The DR5 antigen was more frequent in patients than in the second control group with relative risk of 2,4 and significance at the level of p smaller than 0.05. The p value became insignificant after the correction for the number of antigens investigated.
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