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Rola bialek STAT w chorobach zapalnych i karcynogenezie jelita grubego

100%

Wincewicz A. , Sulkowska M. , Koda M. , Musiatowicz B. , Sulkowski S.

nr 1

23-36

STAT3 and hypoxia induced proteins – HIF-1alpha, EPO and EPOR in relation with Bax and Bcl-xL in nodal metastases of ductal breast cancers

86%

Wincewicz A. , Koda M. , Sulkowska M. , Kanczuga-Koda L. , Wincewicz D. , Sulkowski S.

nr 3

Role of immunohistochemical and histochemical profiling in H and E-based diagnosis of scrotal leiomyosarcoma of dartos muscle

86%

Wincewicz A. , Lewitowicz P. , Sulkowska U. , Sulkowski S. , Horecka-Lewitowicz A. , Koziel D. , Gluszek S.

Folia Histochemica et Cytobiologica

2013

tom 51

nr 4

STAT3, HIF-1alpha, EPO and EPOR - signaling proteins in human primary ductal breast cancers

86%

Wincewicz A. , Sulkowska M. , Koda M. , Lesniewicz T. , Kanczuga-Koda L. , Sulkowski S.

tom 45

nr 2

Clinicopathological significance of Epo, EpoR, Ki-67 and Bax expression in colorectal cancer

72%

Lopmerta K. , Grudzinska M. , Jakubowska K. , Samocik P. , Kozlowski L. , Fudala A. , Wincewicz A. , Koda M.

Progress in Health Sciences

2018

tom 8(2)

112-117

Introduction: Expression of Epo, a glycoprotein secreted by the fetal liver and the adult kidney in response to cellular hypoxia and its receptor have been described in human solid tumors, such as colon and breast cancer. Purpose: Since activation of Epo-EpoR signaling pathway in erythroid progenitor and precursor cells leads to promotion of proliferation and differentiation or prevention of programmed cell death through Bcl-xl and Bcl-2 it was of interest to investigate expression of Epo, EpoR, apoptosis regulator – Bax and marker of proliferating cells - Ki-67 and assess correlation between them, with regard to clinicopathological variables of colorectal cancer. Materials and methods: The correlations between expression of Epo, EpoR, Bax and Ki-67 in colorectal cancer were analyzed in regard to patient age, sex, primary localization, histopathological type, grading, staging and lymph node invasion. Statistical analyses were performed by using the Spearman rank correlation test applying a significance level of p<0,05. Results: Correlation between Bax and EpoR is positive and statistically significant at all groups of patients except group pT1+pT2. Positive correlation between Bax and Epo is statistically significant at following groups of patients: all patients, age  60, age >60, male, female , primary localization in rectum, primary localization in colon, adenocarcinoma, G2, G3. Statistical analysis revealed no significant correlations between expression of neither Ki-67 with Epo nor Ki-67 with EpoR in all groups of patients. Conclusions: Epo seems to be a pleiotropic cytokine, which can exert its biological effect on several cell types, including neoplastic cells. The effect of Epo-EpoR signaling can differ in various cells and conditions.