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3 Polish Journal of Pharmacology

3 1993

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The effect of angiotensin II and its fragments on post-alcohol impairment of learning and memory

100%

Wisniewski K. , Borawska M. , Car H.

Polish Journal of Pharmacology

1993

tom 45

nr 1

23-29

Angiotensin II (1-8) (A II) and its fragments: angiotensin III (2-8) (A III), angiotensin IV (3-8) (A IV), angiotensin V (4-8) (A V) and angiotensin VI (3-7) (A VI) accelerate acquisition of avoidance response and prolong their extinction. A II fragments are devoid classical A II activities such as the effects on blood pressure and thirst. Alcohol administered chronically (for 9 weeks) depresses the ability to retrieve and acquire avoidance responses. The investigated A II fragments counteract the post-alcohol impairment of learning and memory processes (A V being somewhat less active). Fragments A IV and A VI normalize the retrieval in offspring of mothers exposed to alcohol pre- and post-natally.

Psychotropic effects of angiotensin II N-terminal fragments in rats

100%

Holy Z. , Braszko J. , Wisniewski K.

Polish Journal of Pharmacology

1993

tom 45

nr 1

31-41

In this study the effects of angiotensin (AII) angiotensin II hexapeptide [AII(1-6)] and angiotensin II pentapeptide [AII(2-6)] on the motility, stereotypy, learning of conditioned avoidance responses (CARs) and recall of a passive behavior making it possible to avoid averisve stimulation in rats, were compared. All the peptides were injected into the lateral cerebral ventrice (icv) in a dose of 1nmol. AII caused a statistically significant increase in the number of crossings, rearings, and bar approaches in an open field whereas [AII(1-6)] and [AII(2-6)] were inactive in this test. The stereotypic behavior induced by an intraperitoneal (ip) injection of apomorphine (1mg/kg) and amphetamine (7,5 mg/kg) was statistically significantly enhanced only in the rats wihich received AII icv. The application of AII, but not that of [AII(1-6)] and [AII(2-6)] resulted in a quicker acquisition of the CARs. A better recall of passive avoidance was achieved only by AII, while the fragments [AII(1-6)] and [AII(2-6)] had no effect. These findings indicate that the 1-6 and 2-6 fragments of AII do not possess a psychotropic activity like that of the parent ictapeptide.

The effect of vasopressin analog on learning and memory processes in rats with experimental amnesia

100%

Car H. , Borawska M. , Wisniewski K.

Polish Journal of Pharmacology

1993

tom 45

nr 1

11-22

We investigated the effect of a single 2 microg dose of a vasopressin (AVP) analog [d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP on processes of retrieval, consolidation and acquisition of conditioned reflexes in rats with experimentally induced amnesia. The investigated amnesia models were: long term ethanol intoxication, electroconvulsive shocks (ECS), and hypoxia. They all profoundly impaired the learning and memory processes in all tests used. The AVP analog - [d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP facilitated retrieval of passive avoidance in all amnesia models. It improved consolidation of active avoidance of rats previously treated with alcohol, but did not affect the acquisition of active avoidance.[d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP lack antidiuretic properties.