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Studies on the aetiology and treatment of hypophosphataemia developed naturally in cattle from Van region of Turkey

100%

Kaya A. , Akgul Y. , Yuksek N.

Medycyna Weterynaryjna

2008

tom 64

nr 02

The study investigated the aetiology and treatment of cattle with symptoms of lameness, stiff gait and bone fractures in the Van region of Turkey. The study was performed on 200 diseased and 50 healthy cattle aged between 1-8 years old, of both sexes. Blood samples for haematological and biochemical analysis were taken once from the healthy animals and twice from the diseased animals. Fodder samples were also collected. Total protein levels and P values of the diseased animals before treatment compared to the healthy control animals were lower while ALP and Ca were higher. After treatment an increase in the total protein (P < 0.05) and P (P < 0.001) was observed, and a decrease in ALP (P < 0.001), and Ca (P < 0.05). Phosphorus concentrations in the fodder of the diseased animals were significantly lower. Analysis of the haematological, biochemical parameters of the animals and their fodder showed typical changes for hypophosphataemia. The diseased animals were treated by receiving unorganic P and vitamin D₃ injected intramuscularly and mineral suplementation which was administered orally. The animals were observed for 30 days. After treatment, the symptoms observed in the diseased animals disappeared gradually as well as pica symptoms. Supplementing P to the animal’s fodder is vital in order to avoid such problems in the future.

Evaluation of acute phase protein levels and some cytokine levels in pneumonic calves

88%

Akgul O. , Kozat S. , Ozkan C. , Kaya A. , Akgul Y.

Medycyna Weterynaryjna

2019

tom 75

nr 03

This study was carried out to determine the levels of various cytokines (TNF-α, IL-6, IL-8) and acute phase proteins (haptoglobin, C-reactive protein, serum amyloid A, alpha 1-acid glycoprotein, lactoferrin, and fibrinogen) in pneumonic calves, to reveal changes in these parameters depending on etiologic factors (bacterial, viral, bacterial + viral) in calf pneumonia, and to determine whether these parameters could be used for diagnosis and prognosis of the disease. The study was carried out on a total of 50 calves consisting of 10 healthy and 40 pneumonic animals aged 1 to 6 months. The pneumonic calves were classified into three groups: bacterial, viral and mixed (bacterial + viral). It was found that the levels of IL-6, IL-8, CRP, and TNF-α were statistically higher in the pneumonic calves than in the control group animals. It was found that the increase in levels of Serum IL-6, IL-8, and CRP were highest in the mixed infection group (bacterial + viral) and lowest in the virally infected group. Similarly, serum levels of Hp, CRP, SAA, α-1-AGP, and LF were found to be more statistically significant (P <0.01) in the infected calves than in the control group animals, but changes in fibrinogen levels were not statistically significant. Although the TP and ALB levels in the pneumonic calves were numerically higher than the same parameters in the control group, this was not statistically significant (P > 0.05). As a result, this study showed that serum levels of cytokines (IL-6, IL-8, TNF-α) and serum concentrations of acute-phase proteins (Hp, CRP, SAA, α-1-AGP, and LF) are significantly higher in the pneumonic calves than in the control group calves. Furthermore, the assessment of cytokine and acute phase protein levels can play an important role in the early diagnosis of calf pneumonia. This early diagnosis can help prevent deaths caused by pneumonia, which is the leading cause of major losses, and can also be helpful in the early treatment of pneumonia in the veterinary clinical field.