Wyniki wyszukiwania - Biblioteka Nauki

1

Aktualne spojrzenie na klasyfikację przewlekłych chorób żołądka i jelit psów

100%

Ceregrzyn M.

|

nr Dodatek Żywieniowy. Grudzień 2019

2

Biegunki u psów - podwójna rola pokarmu

63%

Glowacka M. , Ceregrzyn M.

|

nr 09

3

Stosowanie glikokortykosteroidów w leczeniu przewlekłej biegunki u psów

63%

Ceregrzyn M. , Janczak D.

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nr 02

4

Zasady wyboru diety u psów z chorobami jelit przebiegającymi z biegunką

63%

Barszczewska B. , Ceregrzyn M.

|

nr 07

5

Zasady postępowania w przypadku wymiotów u psów i kotów

63%

Ceregrzyn M. , Koziol M.

|

nr 11

6

Zapalenie trzustki u psów i kotów

63%

Glowacka M. , Ceregrzyn M.

Magazyn Weterynaryjny. Zeszyt Edukacyjny

|

2018

|

nr 2 (11). Gastroenterologia psów i kotów

7

Kliniczne aspekty zapalenia stawow u psow i kotow

63%

Ceregrzyn M. , Hylmarowa J.

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nr 05

58

8

Analiza aspektów zdrowotnych żywienia psów i kotów surowym pokarmem pochodzenia zwierzęcego

51%

Berwid-Wojtowicz S. , Glowacka M. , Ceregrzyn M.

Magazyn Weterynaryjny. Zeszyt Edukacyjny

|

2018

|

nr 2 (11). Gastroenterologia psów i kotów

9

Indeks zapalenia trzustki u psów i kotów - propozycja diagnostyczna w praktyce weterynaryjnej

51%

Markowska M. , Ceregrzyn M. , Kurska-Krasztel M.

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nr 09

10

The effect of orexins on intestinal motility in vitro in fed and fasted rats

45%

Korczynski W. , Ceregrzyn M. , Kato I. , Wolinski J. , Zabielski R.

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nr 6

43-54

EN

Orexin-A and -B (OXA, OXB) are peptides involved in many gastrointestinal (GI) functions, including motility. Orexins, their precursors and receptors are present in the GI tract. The expression of orexins increases in the hypothalamus and gastrointestinal tract in response to fasting. We have examined the effect of OXA and OXB on GI motility in vitro in fed and fasted rats. The intestinal segments were mounted in chambers filled with Krebs solution. Isotonic contractions were measured in response to acetylcholine (10-5 M), electric field stimulation (EFS), and orexins (10-9-10-7 M) alone or in the presence of orexin-1 type receptor antagonist, SB- 334867 (10-5 M), tetrodotoxin (TTX) 10-6 M, or atropine (10-5 M). Orexins caused a dose-dependent increase of intestinal segment contractions with a more pronounced effect of OXB over OXA. Fasting did not influence orexin-induced responses. Incubation with SB-334867 led to a marked decrease in orexin-induced contractions in OXA-treated segments, while those of OXB were not affected. Atropine diminished contractions only in fasted animals, while TTX led to a decreased response to orexins in both groups. The results show that OXB is predominant in inducing gut motility response, that the effect of orexins is not fully dependent on cholinergic and Na+ transmissions, and that involvement of other transmitters is possible.

11

Central and local (enteric) action of orexins

38%

Korczynski W. , Ceregrzyn M. , Matyjek R. , Kato I. , Kuwahara A. , Wolinski J. , Zabielski R.

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nr 6

17-42

EN

Orexin-A (OXA, hyprocretin-1) and orexin-B (OXB, hypocretin-2) are peptides derived from the same 130 amino acid long precursor (prepro-orexin) that bind and activate two closely related orphan G protein-coupled receptors. Orexins and their receptors were first discovered in the rat brain, and soon after that in peripheral neural structures, including the vagal nerve and enteric nervous system, and in other structures involving the gastrointestinal tract diffuse neuroendocrine system, pancreas tissue, stomach and intestinal mucosa. Orexins and their receptors were also demonstrated in the testes, adrenals, kidneys and placenta. This review is focused on central and enteric actions. Originally, orexins were considered to be neurotransmitters that centrally stimulate food intake in animals and humans, but it soon became evident that their action is broader due to activation of a large number of neuronal pathways involved in energy homeostasis, sleep-awake behavior, nociception, reward seeking, food and drug addiction, as well as reproduction, cardiovascular and adrenal function. In the gastrointestinal tract, orexins have been found so far to affect gastrointestinal motility and gastric, intestinal and pancreatic secretions. The effects were observed following central (intraventricular) or local (intraluminal, intraarterial), but not peripheral (intravenous), administrations of orexins. Since the expression of orexins in the gastrointestinal tract is enhanced during fasting, and fasting reveals many of the orexin gastrointestinal effects, it seems probable that on the local level, orexins keep the gastrointestinal tract functions ready during fasting and play a role in brain-gut axis control.