Wyniki wyszukiwania - Biblioteka Nauki

1

Effect of 7-Nitroindazole on nitric oxide mediated biochemical and morphological alterations evoked by brain ischemia

100%

Chalimoniuk M. , Strosznajder J.

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1997

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tom 57

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nr 5

2

100%

Chalimoniuk M. , Strosznajder J.

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1997

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tom 57

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nr 5

3

Możliwości zastosowania metody tomografii komputerowej (CT) w lotnictwie

100%

Chalimoniuk M. , Kułaszka A.

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2018

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tom nr 3

72--75

PL

W artykule omówione zostały możliwości zastosowania metody CT w lotnictwie. Nowoczesna nieniszcząca metoda diagnostyczna, jaką jest tomografia komputerowa, pozwala na badania praktycznie wszystkich materiałów stosowanych w szeroko rozumianej branży lotniczej - od stopów chromowo - niklowych stosowanych do produkcji łopatek turbinowych, poprzez materiały kompozytowe, aż do nawierzchni lotniskowych. Metoda ta pozwala także na badania całych agregatów, bez konieczności ich demontażu np. podczas badań komisyjnych zdarzeń lotniczych. W artykule pokazano możliwości i ograniczenia zastosowania badań metodą CT na konkretnych przykładach detali lotniczych.

EN

The article describes the possibilities of the application of the CT method in aviation. The modern non-destructive diagnostic method, which is the computer tomography, enables to examine all materials applied in the widely understood aviation industry. From chromium-nickel alloys used to manufacture turbine blades, through composite materials, to runway pavements. This method enables to test all aggregates, without the necessity to dismantle them e.g. during commission tests of aircraft incidents. The article showed the possibilities and limitations of conducting tests with the CT method in particular examples of aircraft details.

4

Exemplification of tomographic method to evaluate the quality of welded joints made from EN 5754-H22 alloy

80%

Błachnio J. , Kułaszka A. , Chalimoniuk M. , Woźny P.

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2016

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tom nr 39

65--78

EN

The quality of welded joints depends on many factors. The relevant standards stipulate technical conditions of welds quality assessment, which provides the basis for stating whether the given joint is compatible with the requirements or whether it is defective. In practice, making welded joints that are totally devoid of defects is extremely difficult. To conduct the control of inner structure of the given joint a non-destructive method with the application of industrial CT scanner might be applied. This modern diagnosing method combines the x-ray examination with advanced computer technology. The basic advantage of computer-assisted tomography consists in examining objects in three dimensions and the possibility to carry out three-dimensional reconstructions. The aim of this article is to discuss the use of this method to evaluate the quality of welded joints made of aluminium alloys. Capabilities of computer-assisted tomography were depicted by the case of weld probes constructed with TIG (ang. Tungsten Inert Gas) welding by different process variables. One has made the analysis of the quality of probes showing the smallest and the biggest internal and external welding defects.

5

31P high resolution NMR spectroscopy in analysis of phosphate-containing compounds of bile

80%

Toczydłowska B. , Piotrowski M. , Chalimoniuk M.

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tom Vol. 31, no. 1

63-71

EN

31P high resolution nuclear magnetic resonance (NMR) spectroscopy was used to examine phospholipid metabolism and to analyze the phosphate-containing compounds in the bile in the transplanted liver recipients, the cholelithiasis patients' and the living donors' groups. Three signals of NMR spectrum of raw bile were determined: inorganic phosphate (Pi), lysophosphatidylcholine (LPtdC), and phosphatidylcholine (PtdC) in all investigated groups. Pi concentration was significantly higher in the recipients' group than in the living donors' group (Mann-Whitney test, p < 0.05). LPtdC and PtdC concentrations were significantly higher (Mann-Whitney test, p < 0.05) in the cholelithiasis patients' group in comparison to the recipients' group. Between the cholelithiasis patients' group and the living donors' group no significant differences in the three analysed compounds were found. The chemometric analysis for the 31P NMR spectral data set provided good classifications between the living donors' and recipients' groups and the poor one among all groups. Results of our study suggest that 31P NMR spectroscopy in vitro may be used for assessment of graft function, for the early signs of rejection and for the predisposition to gallstone formation.

6

Effect of beta-amyloid peptides on cholinergic receptormediated calcium signaling in brain cortex synaptoneurosomes

80%

Samochocki M. , Chalimoniuk M. , Strosznajder J.

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1997

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tom 57

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nr 5

7

Receptor mediated second messengers formation and function in aged brain. Modulatory effect of amyloid beta peptides

80%

Strosznajder J. , Samochocki M. , Chalimoniuk M.

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1997

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tom 57

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nr 5

8

Types Of Damage To Turbines Of Aircraft Turbine Engines And Possibility Of Their Diagnosing

80%

Kułaszka A. , Chalimoniuk M. , Błachnio J.

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tom Vol. 4, no 2

153-160

EN

The article presents the analysis of damage to gas turbine blades influencing the reliability of aircraft turbine engines. Characterised are methods of non-destructive testing and capabilities of applying them to the computer-aided objective diagnosing of condition of blades [3]. The computer-aided diagnosing of condition of gas turbine blades will provide some increase in the reliability of the assessment of blade condition, thus will increase the flight safety and reduce cost of the aircraft engine service.

9

Examination of changes in the microstructure of gas turbine blades with visual and thermographic methods

80%

Błachnio J. , Kułaszka A. , Kornas Ł. , Chalimoniuk M.

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tom Vol. 17, No. 2

27-34

EN

The processes associated with operation of turbinę avionic engines entail the occurrence of various defects affecting turbine components, in particular turbine vanes. The main reasons for defects and deterioration of gas turbine vanes include thermal fatigue and overheating of the vane material. This paper outlines the non-destructive test methods that are currently in use and that are based on an analysis of surface images obtained from the examined parts within the visible bandwidth with the use of a ring-wedge detector. Particular attention is paid to opportunities that enable unbiased diagnostics of changes in the microscopic structure of vanes with the use of the non-destructive thermographic method. Initial examinations ofthe gas turbine vanes, both new ones and those already in operation, have demonstrated the existence of interrelations and dependency between the thermal strain during the turbine operation, changes of signals associated with the thermal response from the material and the condition of the vane microstructures. The results of these examinations have been successfully verified with the use of the metallographic method. The demonstrated interrelations and dependency shall serve as a basis to develop fundamentals for a non-destructive thermographic test method intended to assess the overheating condition of the material for gas turbine vanes.

10

The rate of decohesion of a gas turbine blade as assessed with the X-ray computed tomography (CT)

80%

Chalimoniuk M. , Szczepanik R. , Błachnio J.

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2013

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tom Vol. 20, No. 3

89--96

EN

The overheating of the material is among major reasons for failures/damages to gas turbine blades throughout the entire process of operating aircraft turbine engines. The essential method of diagnosing condition of the blades is metallographic examination being however a destructive technique. The paper has been intended to discuss one of non-destructive testing (NDT) methods, i.e. the X-ray computed tomography (CT), and capabilities of applying it to diagnose changes in condition of gas turbine blades. ‘Tomography’ is a comprehensive term to define a set of diagnostic techniques to produce three-dimensional images that present cross-sections through detail items under scrutiny. The CT is a transmission diagnostic technique that allows layered models (images) of details to be acquired. Most commonly, it is used in research laboratories and throughout the process of the product quality inspection. The paper delivers findings of the preliminary investigation into the assessment of health/maintenance status of gas turbine blades by means of the X-ray computed tomography. The results gained have been successfully verified using the metallographic examination techniques. It has been found that the radiographic imaging method enables recognition of types, sizes, and locations of internal faults in the blades while generating three-dimensional images thereof. Presented are capabilities of the high-resolution X-ray inspection machine with computed tomography (CT), V/tome/x, furnished with a 300 kV tube, and the CT data processing capabilities of the VG Studio Max software solution, high-performance CT reconstruction included (using an optional module). At the same time work is under way with the X-ray tube for nanotomography with the 0.5 􀁐m resolution to examine, in particular, modern composite materials.

11

Ocena wad i niezgodności spawalniczych metodą tomografii komputerowej CT

80%

Kułaszka A. , Chalimoniuk M. , Wieczorowski M. , Brzozowski D.

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tom R. 87, nr 12

31--34

PL

W artykule przedstawiono możliwość zastosowania badań metodą tomografii komputerowej CT do oceny struktury spawów. Metoda tomografii komputerowej w porównaniu do tradycyjnej radiografii daje dużo większe możliwości diagnozowania, kontroli złącz spawanych. Zwiększa się wykrywalność wad i niezgodności spawalniczych, co poprawia bezpieczeństwo eksploatacji. Metodą tomografii możemy dokładnie zwymiarować wadę we wszystkich jej kierunkach i zlokalizować przestrzennie w spoinie, co znacznie ułatwia diagnoście podjęcie ewentualnej decyzji o naprawie spawu lub całkowitym zbrakowaniu wyrobu. W artykule opisano także ograniczenia stosowania metody tomografii rentgenowskiej. Metoda ta jest szeroko wykorzystywana w przemyśle w procesie kontroli jakości produkcji jako metoda nieniszcząca NDT oraz w ramach profilaktycznych badań diagnostycznych.

EN

In the paper a possibility of welding structure inspection by means of computed tomography was presented. In comparison to a traditional radiography, computed tomography method gives much more opportunities to diagnose and inspect welded joints. Thus it is easier to detect defects and discontinuities in weldings, what in turn increases safety of use. Tomography makes it possible to precisely attach to a defect dimensions in all directions and spatially localize it in a joint. This will help to take a decision regarding repair of the joint or consider a workpiece as a scrap. Limits of the use of computer tomography were also described. This solution is widely used in industry in production quality control process as a NDT method as well as in regular prevention diagnosis actions.

12

80%

Strosznajder J. , Koladkiewicz I. , Chalimoniuk M. , Samochocki M.

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tom 58

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nr 2

13

Involvement of multiple protein kinases in cPLA2 phosphorylation, AA release and cell death in astrocyte treated with 1-methyl-4-phenylpyridinium-the possible key role of PKG

71%

Chalimoniuk M. , Stolecka A. , Gabryel B. , Malecki A. , Langfort J.

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nr 1

EN

Cytosolic phospholipase A2 (cPLA2) demonstrates selective affi nity to arachidonic acid (AA) liberation, which is known to be elevated in PD. We indicated that NO/GC/cGMP pathway was upregulated in the primary astrocyte culture treated with MPP+. We investigated if the cGMP/cGMP-dependent protein kinase (PKG) signaling pathway was involved in 1-methyl-4-phenylpyridinium (MPP+)-induced cPLA2 activation of the primary astrocyte culture. We found increased levels of total and phosphorylated cPLA2 and increased AA release in the primary astrocyte culture exposed to MPP+. We used cPLA2-specifi c inhibitors and Ca2+- independent PLA2 (iPLA2), and we found that cPLA2 released more AA after stimulation with MPP+ than iPLA2 and that there was a time-dependent delay of AA release by iPLA2 compared to cPLA2. The PKG inhibitor KT5823 decreased MPP-induced AA release in the primary astrocyte culture. KT5823, in addition to PKC and ERK1/2 inhibitors, decreased cPLA2 activity as well as total and phosphorylated cPLA2 protein levels in the astrocyte treated with MPP+. Dual treatment with PKG and PKC or ERK1/2 inhibitors had the same effect on cPLA2 activity and protein levels. PKG is involved in the enhancement of cPLA2 phosphorylation at Serine-505 and in AA release in the astrocyte exposed to MPP+. Our results indicate that the nNOS/cGMP/ PKG pathway stimulates cPLA2 phosphorylation at Ser-505 by activation of PKC or ERK1/2. These results suggest that activation of cPLA2 by upregulation nNOS/cGMP pathway may play important role in MPP+-induced astrocyte activation, neurotoxicity and oxidative stress in the nigrostriatal system.

14

Glutamate receptors antagonists attenuate neurological deficits and modulate neuroinflammation in Lewis rat subjected to experimental autoimmune encephalomyelitis

71%

Sulkowski G. , Dabrowska-Bouta B. , Chalimoniuk M. , Lenkiewicz A. , Struzynska L.

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tom 73

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nr 1

EN

Experimental autoimmune encephalomyelitis (EAE) is an animal model that mimics many aspects of multiple sclerosis (MS). Chronic or relapsing inflammation of the central nervous system results in the destruction of myelin sheath and cytokines play an important role in the pathogenesis of both MS and EAE. Myelin, oligodendrocytes and neurons are lost due to an inflammatory attack by leukocytes infiltrating the central nervous system (CNS) and releasing cytotoxic cytokines, anti CNS antibodies and large amounts of the excitatory neurotransmitter glutamate. Pharmacological studies have suggested that glutamate receptors mediate white matter injury in a variety of CNS diseases, including multiple sclerosis (MS). Memantine and amantadine are ionotropic glutamate receptors (iGluRs) antagonists. Memantine, a clinically applied drug with N-methyl-D-aspartate (NMDA) receptor antagonistic effects, dose-dependently ameliorates neurological deficits in Lewis rats subjected to experimental autoimmune encephalomyelitis (EAE). The aim of the present study was to investigate the effects of memantine and amantadine on the expression of proinflammatory cytokines such interleukin 1beta (IL-1β), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α) and various chemokines in the brain of EAE rats. Real-time Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and Western Blot were used to analyze the cytokine profile. We noticed increased expression of array of cytokines in experimental group when compared to the control. Dramatic increase of IL-1β, IL-6, TNF-α, and chemokines concentration corresponding to the intensity of neurological symptoms and loss of weight was observed in EAE rats. Administration of iGluR antagonists at an advanced stage of unremitting EAE resulted in amelioration of the disease. Cytokine analysis revealed that memantine significantly decreased the expression of interleukins: IL-6 (65%), IL-1β (60%) and TNF-α (45%) whereas treatment with amantadine reduced only the expression of IL-6 (60%) and TNF-α (15%) when compared to EAE animals. These results show that antagonists of iGlu receptors modulate the course of the disease by reducing the expression of proinflammatory cytokines thereby confirming the involvement of glutamate receptors into pathological mechanisms operating during EAE. This study was supported by grant nr NN401620038 from Polish Ministry of Science and Higher Education

15

Diversity of endurance training effects on antioxidant defenses and oxidative damage in different brain regions of adolescent male rats

61%

Chalimoniuk M. , Jagsz S. , Sadowska-Krepa E. , Chrapusta S. J. , Klapcinska B. , Langfort J.

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2015

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tom 66

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nr 4

16

Effects of IFN-beta1a and IFN-beta1b treatment on the expression of cytokines, inducible NOS (NOS type II), and myelin proteins in animal model of multiple sclerosis

61%

Lubina-Dabrowska N. , Stepien A. , Sulkowski G. , Dabrowska-Bouta B. , Langfort J. , Chalimoniuk M.

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nr 4

17

Diverging oxidative damage and heat shock protein 72 responses to endurance training and chronic testosterone propionate treatment in three striated muscle types of adolescent male rats

51%

Sadowska-Krepa E. , Klapcinska B. , Jagsz S. , Chalimoniuk M. , Chrapusta S. J. , Wanke A. , Grieb P. , Langfort J.

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nr 5

18

Nitric oxide enhances expression and activity of cytosolic phospholipase A2 in PC12 cells with the different amyloid beta load

51%

Chalimoniuk M. , Stolecka A. , Haupmann S. , Schulz K. , Keil U. , Leuner K. , Eckert A. , Muller W. E. , Strosznajder J. B.

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tom 66

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nr 4