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2 Acta Biochimica Polonica

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Stabilizing effect of molecular oxygen complexed to myoglobin on the protein structure

100%

Wozniak-Celmer E. , Gieldon A. , Wozniak M.

tom 53

nr Supplement 1

Signal transmission via G protein-coupled receptors in the light of rhodopsin structure determination

88%

Ciarkowski J. , Drabik P. , Gieldon A. , Kazmierkiewicz R. , Slusarz R.

Acta Biochimica Polonica

2001

tom 48

nr 4

G protein-coupled receptors (GPCRs) transducing diverse external signals to cells via activation of heterotrimeric GTP-binding (G) proteins, estimated to mediate actions of 60% of drugs, had been resistant to structure determination until summer 2000. The first atomic-resolution experimental structure of a GPCR, that of dark (inactive) rhodopsin, thus provides a trustworthy 3D prototype for antagonist-bound forms of this huge family of proteins. In this work, our former theoretical GPCR models are evaluated against the new experimental template. Subsequently, a working hypothesis regarding the signal transduction mechanism by GPCRs is presented.