Wyniki wyszukiwania - Biblioteka Nauki

1

Gemini ester quat surfactants and their biological activity

100%

Luczynski J. , Frackowiak R. , Wloch A. , Kleszczynska H. , Witek S.

Cellular and Molecular Biology Letters

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2013

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tom 18

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nr 1

EN

Cationic gemini surfactants are an important class of surface-active compounds that exhibit much higher surface activity than their monomeric counterparts. This type of compound architecture lends itself to the compound being easily adsorbed at interfaces and interacting with the cellular membranes of microorganisms. Conventional cationic surfactants have high chemical stability but poor chemical and biological degradability. One of the main approaches to the design of readily biodegradable and environmentally friendly surfactants involves inserting a bond with limited stability into the surfactant molecule to give a cleavable surfactant. The best-known example of such a compound is the family of ester quats, which are cationic surfactants with a labile ester bond inserted into the molecule. As part of this study, a series of gemini ester quat surfactants were synthesized and assayed for their biological activity. Their hemolytic activity and changes in the fluidity and packing order of the lipid polar heads were used as the measures of their biological activity. A clear correlation between the hemolytic activity of the tested compounds and their alkyl chain length was established. It was found that the compounds with a long hydrocarbon chain showed higher activity. Moreover, the compounds with greater spacing between their alkyl chains were more active. This proves that they incorporate more easily into the lipid bilayer of the erythrocyte membrane and affect its properties to a greater extent. A better understanding of the process of cell lysis by surfactants and of their biological activity may assist in developing surfactants with enhanced selectivity and in widening their range of application.

2

Aktywność przeciwutleniająca bajkaliny i ekstraktu z tarczycy bajkalskiej oraz ich wpływ na błonę erytrocytów

100%

Wloch A. , Bonarska-Kujawa D. , Sarapuk D. , Oszmianski J. , Kleszczynska H.

Zeszyty Naukowe Uniwersytetu Przyrodniczego we Wrocławiu. Biologia i Hodowla Zwierząt

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2009

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tom 58

3

Acylation stimulating protein is associated with pregnancy weight gain

72%

Sodowski K. , Zwirska-Korczala K. , Kuka D. , Kukla M. , Budziszewska P. , Zebaty A. , Wender-Ozegowska E. , Baumert M. , Wloch A.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 4

33-43

4

Trisomy 18 in neonates: prenatal diagnosis, clinical features, therapeutic dilemmas and outcome

72%

Goc B. , Walencka Z. , Wloch A. , Wojciechowska E. , Wiecek-Wlodarska D. , Krzystolik-Ladzinska J. , Bober K. , Swietlinski J.

Journal of Applied Genetics

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2006

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tom 47

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nr 2

EN

The study aimed to analyse the clinical courses of aggressively treated neonates with cytogenetically confirmed trisomy 18, with special attention focused on the efficiency of prenatal diagnostics, associated malformations, therapeutic dilemmas and outcomes. We investigated retrospectively the data concerning 20 neonates with trisomy 18, admitted to the Neonatal Intensive Care Unit (NICU) in Katowice between January 2000 and February 2005. Their birth weights ranged from 650 g to 2400 g, mean 1812 g; gestational age ranged from 27 to 42 weeks, median 38 weeks. Intrauterine growth retardation was noticed in 90% of neonates. Trisomy 18 was suspected prenatally in 40% of cases. Most (80%) of newborns were delivered by caesarean section (92% of neonates with prenatally unrecognized chromosomal defects, 62% of neonates with trisomy 18 suspicion) and 70% of infants needed respiratory support immediately after birth. Cardiac defects were present in 95%, central nervous system malformations in 65%, severe anomalies of digestive system or abdominal wall in 25% of patients. Nine surgical operations were performed during hospitalization (4 were palliative cardiac surgeries). Six patients (30%) survived the neonatal period and were discharged from the NICU. The median survival of the neonates who died was 20 days. In 4 cases cardiac problems implicated their death; in others, deaths were attributed to multiorgan failure, prematurity and/or infection. Further improvement of efficiency of prenatal ultrasound screening for diagnosis of trisomy 18 in the fetus is necessary. A lack of prenatal diagnosis of trisomy 18 in the fetus results in a high rate of unnecessary caesarean sections in these pregnancies. Despite the aggressive treatment most neonates with trisomy 18 died during the neonatal period. The majority of deaths were attributed to cardiorespiratory and multiorgan failure. Concerning the poor prognosis, prompt karyotyping (using FISH) of clinically suspected trisomy 18 is very important, because many invasive procedures and surgeries may then be avoided.

5

Basal and postprandial gut peptides affecting food intake in lean and obese pregnant women

58%

Sadowski K. , Zwirska-Korczala K. , Kuka D. , Kukla M. , Budziszewska P. , Czuba B. , Wloch A. , Cnota W. , Bielanski W. , Brzozowski T. , Rehfeld J. F. , Zdun R. , Konturek P. C.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 1

37-52

6

Doppler study of the peripheral flows in early gestation

58%

Wloch A. , Sodowski K. , Rozmus-Warcholinska W. , Wloch S. , Bodzek P. , Czuba B. , Borowski D. , Cnota W. , Kuka D. , Szaflik K. , Huhta J.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 4

77-85