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Zachowawcze leczenie zespolu endometritis-pyometra u suk z zastosowaniem aglepristonu

100%

Domoslawska A. , Janowski T.

tom 64

nr 09

1146-1149

The aim of the study was to evaluate the efficacy of aglepristone - a progesterone receptor blocker - in the treatment of endometritis-pyometra complex (EPC) in bitches. 12 bitches of pure and mixed breeds between 2 and 13 years of age with EPC were examined. All animals were treated according to the same pattern: aglepristone (Alizine, Virbac®) was administered at the dose of 0.33 ml/kg, s.c. on days 1, 2, 7, and 14. Additionally, the antibiotic amoxycyline (Clamoxyl, Pfizer®) was administered at the dose of 1 ml/10 kg, s.c. every 48 hours for 10 days. A complete puss mass elimination, uterus involution and improvement of clinical state were observed after 3 weeks of treatment. Progesterone concentration, that was highly increased at the beginning of treatment, decreased to low levels during its first week. The leukocyte count (WBC), alkaline phosphatase (AP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) exceeded normal values before and in the first days of treatment. These parameters improved to normal values after the first week of treatment. The recurrence of EPC was not observed in any bitch during the next 2 years. Three bitches were mated in next heats but did not get pregnant. In the present study the antigestagens therapy proved highly effective: clinical recovery and the recurrence of normal haematological and biochemical counts were observed.

Progesterone level does not distinguish the different course of canine ovulation determined by ultrasonography

80%

Domoslawska A. , Jurczak A. , Janowski T.

nr 2

The aim of this study was to compare progesterone concentrations in bitches during ovulation with a different course of follicular collapse as determined by ultrasonography. The study was conducted on 36 animals of different breeds, from 2 to 7 years old, and from 2 to 44 kg of body weight. Ultrasound examinations of ovaries were conducted in the peri-ovulatory period until ovulation was detected. Based on USG scans the animals were divided into two groups: group A with fast follicular collapse within 1 day, and group B with gradual follicular collapse within 2-3 days. Progesterone measurements were performed in both groups on the day when the beginning of ovulation was diagnosed by USG. Follicular collapse in group A was observed in 27.8% of animals (n=10) and in group B in 72.2% (n=26). There were no statistical differences (p<0.05) in progesterone concentrations between groups A and B (6.68 ± 0.92 ng/ml and 6.81 ± 0.57 ng/ml respectively). From 31 bred bitches (natural mating or insemination) pregnancy was confirmed in 29 females (93.5%). These results provide information about the sufficient stability of progesterone concentration during ovulation regardless of the follicular collapse speed. Ultrasonography during the peri-ovulatory period combined with progesterone measurements allows progress in ovulation management.

Zywienie psow rosnacych

80%

Wisniewska M. E. , Pomianowski A. , Lesnik M. , Domoslawska A.

nr 06

9-11