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The effect of acute stressors and rat strains on the genetic expression in the brain

100%

Trneckova L. , Hynie S. , Klenerova V. , Armario A.

Acta Neurobiologiae Experimentalis

2005

tom 65

nr 5

Modulatory effects of oxytocin and carbetocin on stress-induced changes in rat behavior in the open-field

88%

Klenerova V. , Krejci I. , Sida P. , Hlinak Z. , Hynie S.

Journal of Physiology and Pharmacology

2009

tom 60

nr 2

57-62

Oxytocin (OXY) has been shown to attenuate some of the physiological and behavioral alterations appearing in stressed rats. Carbetocin (CBT), an oxytocin analog [deamino-1-monocarba-(2-O-methyltyrosine)-oxytocin], was designed to exert prolonged action. In the present study we investigated the impact of these peptides on the behavioral changes in rats exposed repeatedly to restraint stressors. Wistar male rats were exposed to restraint for 1 hour; saline or drugs were administered intraperitoneally immediately after stress termination. Recording of the exploratory activity in the open-field started 60 min later. To explore the possibility of persisting effects of stress and/or drugs, the procedure was repeated for three consecutive days. Restraint moderately suppressed locomotion and rearing, and increased grooming. OXY in 0.3 mg/kg dose showed a tendency to restore the suppressed exploratory activity. In contrast, 1 mg/kg dose potentiated the stress-induced behavioral deficit. Both OXY doses slightly increased grooming. CBT in the same two doses restored the stress-induced deficits in locomotion and rearing but did not influence grooming. The locomotor depression after 1 mg dose of OXY was found also in non-stressed rats in contrast to the increased activity after CBT. The data support the view that post-stress administered CBT exerts a significant effect on the stress-altered spontaneous behavior.

Effects of two types of restraint stress on spontaneous behavior of Sprague-Dawley and Lewis rats

88%

Klenerova V. , Sida P. , Krejci I. , Hlinak Z. , Hynie S.

Journal of Physiology and Pharmacology

2007

tom 58

nr 1

The purpose of this study was to evaluate the action of two types of stressors in Sprague-Dawley (S-D) and Lewis (LEW) rats differing in their hypothalamic-pituitary-adrenal axis activity on locomotion and rearing in an open space. Exposure to restraint immobilization alone (IMO) or this immobilization combined with cold water (22 °C) immersion (IMO+C) lasted for 1 h and started 2 or 5 h before the test. To evaluate the acute and persisting effects of both stressors, four trials were performed in one-week intervals; rats were exposed to the stressors in trial 1 and 3. While in LEW rats both acute stressors produced reduction of locomotion and rearing in all stressed groups, S-D rats responded with a decrease of both parameters only after IMO+C presented 2 h before testing. Neither strain displayed a changed performance one week after the first stress exposure. One week after the second stress exposure rats of both strains exhibited a tendency to an increase of both parameters reaching the significance in several experimental groups. The findings indicate: a) the IMO+C produced stronger behavioral alteration than IMO alone; b) the behavioral responses to stressors were more pronounced in LEW compared to S-D strain; c) change from the reduction of activity to its increase may be interpreted as bi-directional manifestation of long-term effects of immobilization stress.