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The effect of luteolin 7-glucoside, apigenin 7-glucoside and Succisa pratensis extracts on NF-κB activation and α-amylase activity in HepG2 cells

100%

Witkowska-Banaszczak E. , Krajka-Kuzniak V. , Papierska K.

tom 67

nr 1

Modulation of cytochrome P450 1A1 expression by tannic acid in rat and mice

100%

Krajka-Kuzniak V. , Szaefer H. , Baer-Dubowska W.

nr Supplement 1

The effect of phytochemicals and their combination on the expression and activity of Nrf2 in human pancreatic cancer cells

100%

Cykowiak M. , Szaefer H. , Krajka-Kuzniak V.

Acta Biochimica Polonica

2018

tom 65

nr S2

Lichen-derived depsides and depsidones modulate the STAT3 signaling pathway in colorectal cancer cells

88%

Papierska K. , Paluszczak J. , Kleszcz R. , Studzinska-Sroka E. , Krajka-Kuzniak V.

Acta Biochimica Polonica

2018

tom 65

nr S2

Modulation of Wnt signaling by natural and synthetic compounds in cancer cells

75%

Paluszczak J. , Kleszcz R. , Majchrzak-Celinska A. , Studzinska-Sroka E. , Krajka-Kuzniak V. , Baer-Dubowska W.

Acta Biochimica Polonica

2018

tom 65

nr S2

The effect of resveratrol and its methylthio-derivatives on the Nrf2-ARE pathway in mouse epidermis and HaCaT keratinocytes

75%

Krajka-Kuzniak V. , Szaefer H. , Stefanski T. , Sobiak S. , Cichocki M. , Baer-Dubowska W.

Cellular and Molecular Biology Letters

2014

tom 19

nr 3

Resveratrol is the most extensively studied stilbene derivative. We previously showed that methylthiostilbenes were more effective inhibitors of CYP1A1 and 1B1 activity than resveratrol. In this study, we investigated whether resveratrol and its methylthio-substituted derivatives, i.e. 3-M-4′-MTS (S2), 3,5-DM-4′-MTS (S5) and 3,4,5-TM-4′-MTS (S7) could activate Nrf2 signaling in the mouse epidermis and in human keratinocytes. Western blot analysis showed translocation of Nrf2 from the cytosol to the nucleus in both models. All of the tested stilbenes increased GST activity, but resveratrol was the most effective inducer. Moreover, only resveratrol increased the protein level of GSTP in the mouse epidermis. GSTM was enhanced in HaCaT cells after the treatment with derivatives S2 and S5. The same effect was observed for GSTP in the case of compound S2. Resveratrol and its derivatives reduced the NQO2 protein level in HaCaT cells. Thus, it is possible that increased expression of GSTP or GSTM and GST activity was linked with NQO2 inhibition in these cells. The results of this study indicate that resveratrol and its methylthioderivatives activate Nrf2 not only in the mouse epidermis, but also in human keratinocytes. Upregulating GST isozymes might be particularly important for deactivating chemical carcinogens, such as PAH.

Modulation of NF-κB signaling pathway by oleanolic acid derivatives and its conjugates with non-steroidal anti-inflammatory drugs in hepg2 hepatocellular cells line

75%

Narozna M. , Krajka-Kuzniak V. , Szaefer H. , Paluszczak J. , Bednarczyk-Cwynar B. , Baer-Dubowska W.

Acta Biochimica Polonica

2018

tom 65

nr S2