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Komórki NKT jako element łączący odporność wrodzoną z odpornością nabytą

100%

Kaszubowska L. , Piotrowska A. , Siedlecka-Kroplewska K. , Kmiec Z.

tom 40

nr 4

Nowe mechanizmy aktywacji komórek NK w przebiegu infekcji wirusowych

100%

Slebioda T. J. , Kaszubowska L. , Kmiec Z.

nr 1

NKT-like cells reveal higher than T lymphocytes expression of cellular protective proteins HSP70 and SOD2 and comparably increased expression of SIRT1 in the oldest seniors

100%

Kaszubowska L. , Foerster J. , Kwiatkowski P. , Schetz D.

nr 4

Treatment of Graves’ disease with methimazole in children alters the proliferation of Treg cells and CD3+ T lymphocytes

63%

Klatka M. , Kaszubowska L. , Grywalska E. , Wasiak M. , Szewczyk L. , Foerster J. , Cyman M. , Rolinski J.

tom 52

nr 1

Transforming growth factor beta1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts

51%

Liberek A. , Kmiec Z. , Wierzbicki P. M. , Jakobkiewicz-Banecka J. , Liberek T. , Luczak G. , Plata-Nazar K. , Slominska-Fraczek M. , Kaszubowska L. , Gabik-Ciminska M. , Wegrzyn A.

2013

tom 60

nr 4

Previously published studies on levels of the transforming growth factor-β1 (TGF-β1) protein and mRNA of the corresponding gene in patients suffering from inflammatory bowel diseases (IBD) gave varying results, leading to contradictory conclusions. To solve the contradictions, we aimed to assess longitudinally TGF-β1 protein and mRNA levels at different stages of the disease in children suffering from IBD. The study group consisted of 19 pediatric patients with IBD at the age between 3.5 and 18.4 years. The control group consisted of 42 children aged between 2.0 and 18.0 years. The plasma TGF-β1 concentration was measured with ELISA. mRNA levels of the TGF-β1 gene isolated from samples of the intestinal tissue were assessed by reverse transcription and real-time PCR. Levels of TGF-β1 protein in plasma and corresponding mRNA in intestinal tissue were significantly higher in IBD patients than in controls. TGF-β1 and corresponding transcripts were also more abundant in plasma and intestinal tissue, respectively, in patients at the active stage of the disease than during remission. In every single IBD patient, plasma TGF-β1 level and mRNA level in intestinal tissue was higher at the active stage of the disease than during remission. Levels of TGF-β1 and corresponding mRNA are elevated during the active stage of IBD but not during the remission. Longitudinal assessment of this cytokine in a single patient may help to monitor the clinical course of IBD.