Wyniki wyszukiwania - Biblioteka Nauki

Ten serwis zostanie wyłączony 2025-02-11.

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

Znaleziono wyników: 5

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Arrheton - Unspeakable in the Greek Mystery Cults

100%

Bielawski K.

Filozofia Chrześcijańska

2016

tom 13

37-52

The paper presents meaning and use of two technical words important for understanding and interpretation of the ancient mystery cults and mystical experience of ancient Greeks: arrheton and aporrheton – “unspeakable” and “forbidden”. The introduction contains general guidelines of so called “Greek religion” with its focus on performance and ritual and describes the rôle of mystery cults in the frame of this adogmatic religious system. The paper explains lexicography of the crucial terms, including etymology, ancient vocabularies and grammar and then turns to the catalogue and interpretation of the most important literary and epigraphical evidence on the use and meaning of arrheton in the Greek culture. The catalogue contains Aristotle, Xenophon, Herodotus, Aristophanes, Euripides, Sophocles, Apuleius and Derveni Papyrus as well as early Christian writers.

New carbocyclic analogues of netropsin: Synthesis and inhibition of topoisomerases.

51%

Pućkowska A. , Bielawski K. , Bielawska A. , Róański A.

Acta Biochimica Polonica

2002

tom 49

nr 1

177-183

A series of carbocyclic analogues of netropsin were synthesized and evaluated for their capacity to inhibit human topoisomerases I and II in vitro. The compounds are oligopeptides containing 1,4-di- and 1,2,5-trisubstituted benzene rings and unsubstituted N-terminal NH2 groups. Compounds 4-7 consist of two netropsin-like units linked by aliphatic (tetra- and hexamethylene) chains. In the topoisomerase I and II assay, the relaxation of pBR322 plasmid was inhibited by compounds 4-7 at 100 μM concentration.

Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2.

51%

Bielawski K. , Bielawska A. , Bartulewicz D. , Różański A.

Acta Biochimica Polonica

2000

tom 47

nr 3

855-866

A molecular mechanics and molecular dynamics approach was used to examine the structure of complexes formed between the d(CGCGAATTCGCG)2 duplex and netropsin, distamycin, and four carbocyclic analogues of netropsin and distamycin (1-4). The resulting structures of the ligand-DNA model complexes and their energetics were examined. It is predicted that the compounds 1-4 should have a decreased affinity for the minor groove of AT-rich regions in comparison to netropsin and distamycin. From the energetic analysis it appears that van der Waals and electrostatic interactions are more important than specific hydrogen bonds in stabilizing the ligand-duplex complexes. We predict that compounds 1 and 2 are effectively isohelical with the DNA minor groove. The superior DNA-binding afforded by 1 and 2 in comparison to 3 and 4 results from their more effective penetration into the minor groove and smaller perturbation of molecular structure upon complex formation.

Construction of a DNA-polymerase I overproducing plasmid and isolation of the enzyme

38%

Bielawski K. , Skowron P. , Kur J. , Konopa G. , Podhajska A. , Taylor K.

nr 1

29-34

Synthetic analogues of netropsin and distamycin - synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics

38%

Bartulewicz D. , Bielawski K. , Markowska A. , Zwierz K. , Pućkowska A. , Różański A.

Acta Biochimica Polonica

1998

tom 45

nr 1

41-57