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Wybrane zagadnienia fizykochemii koloidów w procesach inhalacyjnego dostarczania leków do płuc

100%

Sosnowski T. R. , Dobrowolska K.

Wiadomości Chemiczne

2021

tom [Z] 75, 9-10

1376--1393

The paper highlights selected problems of physical chemistry and dynamics of colloidal systems indispensable for the understanding and optimization of drug delivery by inhalation. Besides describing the fundamental aspects of aerosol flow and deposition in the respiratory system, some problems related to particle or droplet generation in the inhalers are discussed. In particular, the influence of liquid properties on aerosol formation in different nebulizers is demonstrated as a critical factor in successful aerosol therapy. The paper also addresses interactions between inhaled drug particles and bronchial mucus or the pulmonary surfactant, indicating another broad field of colloid and interface science application in medicine.

Evolution of droplet size distribution in selected nebulizers

100%

Dobrowolska K. , Sosnowski T. R.

Physicochemical Problems of Mineral Processing

2020

tom Vol. 56, iss. 6

32--40

Nebulizers are the class of atomizing devices used to disperse liquids to fine droplets. They found their application in selected technological (typically: small-scale) processes, but their most common use is related to the generation of medicinal aerosols for inhalation. In this work we present the experimental data on the evolution of the size distributions of water droplets generated by two nebulizers (pneumatic and vibrating-mesh) as a result of aerosol mixing with the ambient air. Such a process reflects the real situation, where aerosol emitted from a nebulizer is diluted by additional air sucked by a patient during inhalation. Droplet size distribution was determined by laser diffraction, and these results were further discussed including the data of the aerosol velocity measured by the Laser Doppler Anemometry (LDA). It was demonstrated – as expected - that dilution with the ambient air with moderate humidity results in the intense evaporation of the smallest droplets. However, larger droplet may be saved to a different degree depending on the velocity and geometry of the aerosol cloud emitted from the nebulizer, and on the volume of the diluting air. These parameters have an influence on the droplet coalescence which is another process shaping the droplet size distribution in the studied conditions. The results can deepen the understanding of the mist dynamics which can be applied in various fields of colloidal science and technology.