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Role of the mitochondrial ATP-sensitive Kplus channels in cardioprotection

100%

Ardehali H.

Acta Biochimica Polonica

2004

tom 51

nr 2

The mitochondrial ATP-sensitive K+ (mitoKATP) channel was discovered more than a decade ago. Since then, several pharmacological studies have identified agents that target this channel some of which selectively target mitoKATP. These and other studies have also suggested that mitoKATP plays a key role in the process of ischemic preconditioning (IPC) and prevention of apoptosis. The mechanism by which mitoKATP exerts its protective effects is unclear, however, changes in mitochondrial Ca2+ uptake and levels of reactive oxygen species, and mitochondrial matrix swelling are believed to be involved. Despite major advances, several important issues regarding mitoKATP remain unanswered. These questions include, but are not limited to: the molecular structure of mitoKATP, the downstream and upstream mechanisms that leads to IPC and cell death, and the pharmacological profile of the channel. This review attempts to provide an up-to-date overview of the role of mitoKATP in cardioprotection.

Matrix metalloproteinase 9/neutrophil gelatinase associated lipocalin/tissue inhibitor of metalloproteinases 1 complexes are localized within cardiomyocytes and serve as a reservoir of active metalloproteinases in porcine female myocardium

26%

Kiczak L. , Tomaszek A. , Bania J. , Paslawska U. , Zacharski M. , Janiszewski A. , Rybinska I. , Dziegiel P. , von Haehling S. , Ardehali H. , Jankowska E. A. , Ponikowski P.

Journal of Physiology and Pharmacology

2014

tom 65

nr 3