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Pierwotne zapalenie mózgu i opon mózgowo-rdzeniowych (PAM) wtwołane przez Naegleria fowleri

100%

Jaskowski J. M. , Zuraw A. , Rybska M.

tom 70

nr 07

Naegleria fowleri is a pathogenic amoeba that propagates in fresh water. It causes severe meningoencephalitis in infected humans (PAM, primary amebic meningoencephalitis). The mortality rate of this disease reaches over 99%. Most of the cases have been reported in the United States and have occurred mostly in summer. The prevalence of the disease in animals has been significantly lower than in man so far. Cases have been reported in cows, sheep, gibbons, gorillas, and tapirs, and experimental infections have been induced in mice. Meningoencephalitis is accompanied by progressive neurological signs. In the necropsy, the thickening of the meninges and multifocal areas of cerebral and cerebellar malacia are diagnosed. Histologically, a multifocal, necrosuppurative meningoencephalitis with areas of mallacia containing ameba trophoziotes are visible. The diagnosis of the disease is difficult. Ameba may be detected in the cerebro-spinal fluid, but often only after a culture of necropsy samples has been performed. The following techniques are used to diagnose the disease: immunofluorescent staining, light and confocal microscopy, ELISA, PCR, and RQ-PCR.

Istotne aspekty oddziaływania wybranych czynników wzrostu na funkcjonowanie układu rozrodczego samic

100%

Wozna M. , Rybska M. , Swierczewska M. , Jaskowski J. M.

nr 06

The endometrium of the uterus is a highly dynamic structure in terms of its changes during the various stages of the sexual cycle. These changes are the result of cyclical fluctuations in the concentrations of steroid hormones and local factors of an auto – and paracrine – nature. This condition indicates that the causes of degenerative processes of the uterus must be sought not only in disorders of the hormonal profile and bacterial infections but also disorders at the molecular level. Factors that may play a key role in the formation and development of various pathologies of the female reproductive system include growth factors and their receptors (growth factors – GFs). Discussing these growth factors in the work may provide useful molecular markers that identify pathological conditions of the endometrium. Subject to expression in the endometrium, they are involved in the regulation of cell proliferation, migration and secretion of the glandular epithelium, they also regulate physiological and pathological angiogenesis, revealing strong pro-inflammatory effects. In this research, the authors present an overview of current scientific reports indicating that changes in the expression of studied factors, and thus disturbances in their effects, may constitute one of the causes of pathogenesis within the uterus in many animal species.

Wpływ rodzaju materiału spodowego na poślizg obuwia

88%

Rybska M. , Wisnios E. , Bienkowski S.

Przegląd Skórzany

1989

tom 44

nr 04

Rola cytokin z rodziny TGF-beta w procesie folikulogenezy, oogenezy oraz dojrzewania oocytów u ssaków

51%

Rybska M. , Kempisty B. , Swierczewska M. , Wozna M. , Ciesiolka S. , Piotrowska H. , Antosik P. , Bukowska D. , Jopek K. , Bruska M. , Nowicki M. , Jaskowski J. M.

Medycyna Weterynaryjna

2015

tom 71

nr 07

The process of oocytes maturation in mammals is regulated by the expression of many types of cell-specific genes. Both nuclear and cytoplasmic maturation is based on activation of biochemical and metabolic pathways that lead to reaching the full maturation stage (MII) of oocytes. The most recent data indicates that the proteins belonging to transforming the growth factor beta (TGF-β) superfamily play an important role in the process of oocytes maturation, as well as of reaching full developmental capacity by these cells. Moreover, it has been clearly showed that the proteins belonging to TGF-β such as inhibins (INHA, INHB) and activins regulate both folliculo- and oogenesis by the stimulation and/or inhibition of several biochemical pathways. In this review, the most recent knowledge about the role of proteins belonging to TGF-β superfamily in the regulation of folliculogenesis, oogenesis and oocytes maturation has been presented and discussed.