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1 Acta Neurobiologiae Experimentalis

1 2015

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The new derivate of kisspeptine-54-kissorphin (KSO) reduces the expression of morphine-and ethanol-induced conditioned place preference in rats

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Gibula-Bruzda E. , Kotlinska J. H. , Marszalek-Grabska M. , Trzcinska R. , Silberring J.

Acta Neurobiologiae Experimentalis

2015

tom 75

nr Supl.

BACKGROUND AND AIMS: The kisspeptins (KP) are a family of peptide hormones, which in recent years have been shown to play a crucial role in the regulation of the hypothalamic–pituitary–gonadal axis, thus in turn influence fertility and reproduction. One of the fragments of KP-54 termed Kissorphin (KSO) shares amino acid similarities with the biologically active sequence of NPFF therefore it is possible that KSO could exhibit NPFF-like activity (Simonin et al. 2006) without influence on concentration of gonadotropinreleasing hormone (Roseweir et al. 2009, Milton 2012). This is particularly important since the NPFF may participate to the control of the mesocorticolimbic dopamine system activity by counteracting the effect of many psychostimulants (Marco et al. 1995, Cador et al. 2002). Therefore the aim of the present study was to investigate whether a KSO (Tyr-Asn-Trp-Asn-Ser-Phe-NH2) influence the expression of morphine- and ethanol-induced CPP. METHODS: Morphine- and ethanol-induced CPP were induced according to the previously established methods (Kotlinska et al. 2007). RESULTS: Our experiments showed that KSO, given intravenously (iv) at the doses of 1, 3 and 10 nmol/300 µl, inhibited the expression of both morphine and ethanol-induced CPP. KSO gave itself, neither induced place preference nor aversion. CONCLUSIONS: These results suggest that KSO is involved in the expression of morphine and ethanol reward. Moreover, our study supports an anti-opioid character of this peptide.