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Gen dehydrogenazy mleczanowej-A wyznacznikiem dzielnosci lotowej golebia pocztowego?

100%

Dybus A. , Pijanka J. , Szatkowska I. , Zych S.

nr 10

1114-1118

Polymorphism within the LDHA gene in the homing and non-homing pigeons

75%

Dybus A. , Pijanka J. , Cheng Y. H. , Sheen F. , Grzesiak W. , Muszynska M.

tom 47

nr 1

A total of 445 domestic pigeons were genotyped for the lactate dehydrogenase (LDHA) gene. Crude DNA was isolated from blood samples and feathers. Two polymorphic sites were identified in intron 6: one near the splice donor site GT is called site H and the other near the splice acceptor site is called site B. Interestingly, the nucleotide changes of both these sites associate perfectly with the A and B alleles of HaeIII polymorphism: the A allele with nucleotide A of site H and nucleotide T of site B; while the B allele with nucleotide G of site H and nucleotide G of site B. In this study, we have identified the molecular difference between alleles A and B of the pigeon LDHA gene. The difference at site H in intron 6 explains the Hae III polymorphism. The frequencies of LDHA AB and LDHA BB genotypes between the analysed groups differ significantly (P < 0.001); the LDHA A allele was more frequent in the groups of pigeons with elevated homing performance (P < 0.001). The functional difference may be due to the change at site B, the potential splice branch site. Since LDHA activity is associated with the homing ability, it is possible that during the process of selection for the homing ability, the LDHA A allele has been selected, and is more prevalent in the top-racing groups.