Cardiovascular complications during the treatment of castration-resistant prostate cancer with the use of modern antiandrogens: abiraterone acetate and enzalutamide

• Autorzy: , , Agnieszka Chmielewska
• Języki publikacji: EN

Abstrakty

EN

Modern antiandrogens: abiraterone acetate (inhibitor of CYP17 cytochrome) and enzalutamide (irreversible inhibitor of androgen receptor) are the drugs that are increasingly often administered in treatment of castration-resistant prostate cancer. Despite their clinical efficacy, especially in terms of prolonged survival and improved quality of life of patients, they pose of problem for a practicing oncologist such as possible cardiovascular complications (particularly arterial hypertension), which may lead to the cessation of this form of therapy. This article provides a brief overview of the mechanisms responsible for the above complications, including practical recommendations in the event such complications arise. A simple scheme of action for control of cardiovascular risk factors has been presented, which can improve the prognosis in this population of patients.

Słowa kluczowe

EN

abiraterone acetate; cardiovascular complications; castration resistant prostate cancer; enzalutamide

• Wydawca: Medical Education
• Czasopismo: OncoReview
• Rocznik: 2021
• Tom: 11
• Numer: 3
• Strony: 61-67

Twórcy

autor

,

• 1. Department of Internal Medicine, Gastroenterology and Oncological Cardiology, Warmian- -Masurian Cancer Center of the Ministry of the Interior And Administration’s Hospital, Olsztyn, Poland. 2. Pulmonology Clinic, Collegium Medicum, Univesity of Warmia and Mazury, Olsztyn, Poland,

autor

Agnieszka Chmielewska

• Oncology and Immunooncology Clinic, Warmian-Masurian Cancer Center of the Ministry of the Interior and Administration’s Hospital, Olsztyn, Poland

Bibliografia

• 1. Krajowy Rejestr Nowotworów (access: 12.07.2021).
• 2. Epstein MM, Edgren G, Rider JR et al. Temporal trends in cause of death among Swedish and US men with prostate cancer. J Natl Cancer Inst. 2012; 104: 1335-42. http://doi.org/10.1093/jnci/djs299.
• 3. Nguyen PL, Alibhai SMH, Basaria S et al. Adverse effects of androgen deprivation therapy and strategies to mitigate them. Eur Urol. 2015; 67(5): 825-36.
• 4. Tzortzis V, Samarinas M, Zachos I et al. Adverse effects of androgen deprivation therapy in patients with prostate cancer: focus on metabolic complications. Hormones (Athens). 2017; 16: 115-23. https://doi.org/10.14310/horm.2002.1727.
• 5. Gupta D, Lee Chuy K, Yang JC et al. Cardiovascular and metabolic effects of androgen-deprivation therapy for prostate. Cancer Oncol Pract. 2018; 14(10): 580-7.
• 6. Keating NL, O’Malley AJ, Smith MR. Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. J Clin Oncol. 2006; 24: 4448-56. https://doi.org/10.1200/JCO.2006.06.2497.
• 7. Guo Z, Huang Y, Gong L et al. Association of androgen deprivation therapy with thromboembolic events in patients with prostate cancer: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 2018; 21: 451-60.
• 8. Rehman Y, Roseberg JE. Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer. Drug Des Devel Ther. 2012; 6: 13-8.
• 9. Charakterystyka produktu leczniczego Zytiga® (access: 12.07.2021).
• 10. Fizazi K, Tran N, Fein L et al. Abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer. N Engl J Med. 2017; 377: 352-60. https://doi.org/10.1056/NEJMoa1704174.
• 11. Zhu X, Wu S. Risk of hypertension in Cancer patients treated with Abiraterone: a meta-analysis. Clin Hypertens. 2019; 25: 5. https://doi.org/10.1186/s40885-019-0110-3.
• 12. vanDorst DCH, Dobbin SJH, Neves KB et al. Hypertension and prohypertensive antineoplastic therapies in cancer patients. Circ Res. 2021; 128: 1040-61.
• 13. Xtandi – charakterystyka produktu leczniczego (access: 12.07.2021).
• 14. Schalken J, Fitzpatrick JM. Enzalutamide: targeting the androgen signalling pathway in metastatic castration‐resistant prostate cancer. BJU Int. 2016; 117(2): 215-25.
• 15. Scher HI, Fizazi K, Saad F et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med. 2012; 367: 1187-97. https://doi.org/10.1056/NEJMoa1207506.
• 16. Beer TM, Armstrong AJ, Rathkopf DE et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N Engl J Med. 2014; 371: 424-33. https://doi.org/10.1056/NEJMoa1405095.
• 17. Hussain M, Fizazi K, Saad F et al. Enzalutamide in men with nonmetastatic, castration-resistant prostate cancer. N Engl J Med. 2018; 378: 2465-74. https://doi.org/10.1056/NEJMoa1800536.
• 18. Salem JE, Yang T, Moslehi JJ et al. Androgenic effects on ventricular repolarization: a translational study from the international pharmacovigilance database to iPSC-cardiomyocytes. Circulation. 2019; 140: 1070-80. https://doi.org/10.1161/CIRCULATION AHA.119.040162.
• 19. Attard G, Reid AH, Auchus RJ et al. Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer. J Clin Endocrinol Metab. 2012; 97(2): 507-16.
• 20. Kosicka K, Główka FK, Kośla A et al. Rola glikokortykosteroidów w etiologii nadciśnienia tętniczego. Nadciśnienie Tętnicze. 2010; 14(3): 208-15.
• 21. Bhatia N, Santos M, Jones LW et al. Cardiovascular effects of androgen deprivation therapy for the treatment of prostate cancer. Circulation. 2016; 133; 5: 537-41.
• 22. Williams B, Mancia G, Spiering W et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018; 39: 3021-104.
• 23. Tykarski A, Filipiak KJ, Januszewicz A et al. Zasady postępowania w nadciśnieniu tętniczym – 2019 rok. Wytyczne Polskiego Towarzystwa Nadciśnienia Tętniczego. Nadciśnienie Tętnicze w Praktyce. 2019; 5: 1-86.
• 24. Mc Menamin UC, Murray LJ, Cantwell MM et al. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in cancer progression and survival: a systematic review. Cancer Causes Control. 2012; 23: 221-30.
• 25. Gill D, Gaston D, Bailey E et al. Efficacy of eplerenone in the management of mineralocorticoid excess in men with metastatic castration-resistant prostate cancer treated with abiraterone without prednisone. Clin Genitourin Cancer. 2017; 15(4): e599-602.
• 26. Dhondt B, Buelens S, Van Besien J et al. Abiraterone and spironolactone in prostate cancer: a combination to avoid. Acta Clin Belg. 2019; 74(6): 439-44. https://doi.org/10.1080/17843286.2018.1543827.

• Typ dokumentu: article