Tissue remodelling in chronic rhinosinusitis – review of literature

• Autorzy: Radajewski, Kamil , Wierzchowska, Małgorzata , Grzanka, Dariusz , Antosik, Paulina , Zdrenka, Marek , Burduk, Paweł

Abstrakty

EN

CRS is a process involving a number of adverse changes in the mucosa of the paranasal sinuses and nasal polyps, e.g. increased fibroblast proliferation, angiogenesis, increased formation of fibrous tissue (subepithelial fibrosis) and tissue destruction. There are biomarkers whose levels can be increased in chronic inflammation of the paranasal sinuses: peripheral blood eosinophilia, IgE immunoglobulin, cytokines – IL-4, IL-5, IL-13, IL-25, IL-33, periostin, P-glycoprotein, CXCL-12, CXCL-13, INF-Υ, TNFα, TGFβ1, albumins, eotaxin. These biomarkers are not pathognomonic for CRS. The concentration of biomarkers is also increased in bronchial asthma and atopic dermatitis. The TGFβ, in particular the β1 subunit, was identified as the main factor involved in the remodelling of tissue stroma. In conjunction with continuous improvement of tissue testing methods, it is advisable to search for new factors that will more accurately allow the assessment of tissue remodelling in the chronic processes of paranasal sinuses.

Słowa kluczowe

EN

chronic rhinosinusitis; nasal polyps; tissue remodeling

• Czasopismo: Otolaryngologia Polska
• Rocznik: 2019
• Tom: 73(5)
• Strony: 1-4

Daty

wydano

2019-09-02

Twórcy

autor

Radajewski, Kamil

autor

Wierzchowska, Małgorzata

autor

Grzanka, Dariusz

autor

Antosik, Paulina

autor

Zdrenka, Marek

autor

Burduk, Paweł

Identyfikatory

DOI

10.5604/01.3001.0013.4121