Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2013 | 62 | 1 |
Tytuł artykułu

Efficiency of selected mutagens in generating Xanthophyllomyces dendrorhous strains hyperproducing astaxanthin

Autorzy
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Astaxanthin is a xanthophill pigment with commercial application in the aquaculture, pharmaceutical, food and cosmetic industries. The red yeast Xanthophyllomyces dendrorhous is one of the most promising microorganisms for its industrial production. However, astaxanthin content in wild yeast strains is low. Pigment production by X. dendrorhous can be improved by mutagenesis. The aim of the study was to assess the efficiency of four mutagens: UV radiation, benomyl, ethyl methanesulfonate and ethidium bromide in generating asthaxanthinhyperproducing strains of the yeast Xanthophyllomyces dendrorhous DSM 5626. Mutations with benomyl, ethidium bromide and UV radiation generated a group of hyperpigmented mutants exhibiting increases up to 100% in astaxanthin content. Ethyl methanesulfonate turned out to be useless in this respect.
Wydawca
-
Rocznik
Tom
62
Numer
1
Opis fizyczny
p.67-72,ref.
Twórcy
  • Institute of Technology of Plant Origin Food, Poznan University of Life Sciences, Wojska Polskiego 31, 60-624 Poznan, Poland
Bibliografia
  • Baeza M., P. Retamales, D. Sepúlveda, P. Lodato, A. Jiménez and V. Cifuentes. 2009. Isolation, characterization and long term preservation of mutant strains of Xanthophyllomyces dendrorhous. J. Basic. Microbiol. 49: 135–141.
  • Bon J.A., T.D. Leather and R.K Jayaswal. 1997. Isolation of astaxanthin-overproducing mutants of Phaffia rhodozyma. Biotechnol. Lett. 19: 109–112.
  • Breithaupt D.E. 2007. Modern application of xanthophylls in animal feeding – a review. Trends in Food Sci. Technol. 18: 501–506.
  • Calo P., J.B. Velázquez, C. Sieiro, P. Blanco, E. Longo and T.G. Villa. 1995. Analysis of astaxanthin and other carotenoids from several Phaffia rhodozyma mutants. J. Agric. Food. Chem. 43: 1396–1399.
  • Chumpolkulwong N., T. Kakizono, S. Naga and N. Nishio. 997. Increased astaxanthin production by Phaffia rhodozyma mutants isolated as resistant to difenylamine. J. Ferment. Bioeng. 83: 429–434.
  • Dizdaroglu M. 2012. Oxidatively induced DNA damage: Mechanisms, repair and disease. Cancer. Lett. 327: 26–47.
  • Dominíguez-Bocanegra A.R and J.A. Torres-Muñoz. 2004. Astaxanthin hyperproduction by Phaffia rhodozyma (now Xanthophyllomyces dendrorous) with raw milk as sole source of energy. Appl. Microbiol. Biotechnol. 66: 249–252.
  • Flenø B., I. Christensen, R. Larsen, S.R. Johansen and E. Johnson. 1997. Astaxanthin-producing yeast cells, methods for their preparation and their use. US Patent No. 5, 599, 711.
  • Fontana J.D., M.F. Guimrães, N.T. Martins, C.A. Fontana and M. Baron. 1996. Culture of the astaxanthinogenic yeast Phaffia rhodozyma in low-cost media. Appl. Biochem. Biotechnol. 57: 413–422.
  • Girard P., C.E.J. Javelot and B.D.V. Vladescu. 1997. Phaffia rhodozyma mutants, process for producing β-carotene and use of β-carotene rich biomass. US Patent No. 5, 691,190.
  • Golubev W.I. 1995. Perfect state of Rhodomyces dendrorhous (Phaffia rhodozyma). Yeast 11: 101–110.
  • Goswami G., S. Chaudhuri and D. Dutta. 2010. The present perspective of astaxanthin with reference to biosynthesis and pharmacological importance. World. J. Microbiol. Biotechnol. 26: 1925–1939.
  • Gramza-Michałowska A. and B. Stachowiak. 2010. The antioxidant potential of carotenoid extract from Phaffia rhodozyma. Acta Sci. Pol. Technol. Aliment. 9: 171–188.
  • Hermosilla G., C. Martínez, P. Retamales, R. León and V. Cifuentes. 2003. Genetic determination of ploidy level in Xanthophyllomyces dendrorhous. Antonie van Leeuwenhoek 84: 279–287.
  • Johnson E.A. and M. Lewis. 1979. Astaxanthin formation by the yeast Phaffia rhodozyma. J. Gen. Microbiol. 115: 173–183.
  • Kim S.K., J.H. Lee, C.H. Lee and Y.C. Yoon. 2007. Increased carotenoid production in Xanthophyllomyces dendrorhous G276 using plant extracts. J. Microbiol. 45: 128–132.
  • Liu Y.S. and J.Y. Wu. 2006. Hydrogen peroxide-induced astaxanthin biosynthesis and catalase activity in Xanthophyllomyces dendrorhous. Appl. Microbiol. Biotechnol. 73: 663–668.
  • Malik A. and A. Czajka. 2012. Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction? Mitochondrion DOI: MITOCH-00764.
  • Pfeiffer I., C. Vágvölgy, T. Hirano and J. Kucsera. 2010. Characterization of petite mutants of the basidiomycetes Phaffia rhodozyma CBS 5905. Acta Biol. Szeged. 54: 143–148.
  • Potargowicz E., E. Szerszenowicz, M. Staniszewska and D. Nowak. 2005. Mitochondria as a source of reactive oxygen species. Postepy Hig. Med. Dosw. 59: 259–266.
  • Ramírez J., M.L. Nuñez and R. Valdivia. 2000. Increased astaxanthin production by a Phaffia rhodozyma mutant grown on date juice from Yucca fillitera. J. Ind. Microbiol. Biotechnol. 24: 187–190.
  • Rodríguez-Sáiz M. and J.L. de la Fuente. 2010. Xanthophyllomyces dendrorhous for the industrial production of astaxanthin. Appl. Microbiol. Biotechnol. 88: 645–658.
  • Sedmak J.J., D.K. Weerasinghe and S.O. Jolly. 1990. Extraction and quantification of astaxanthin from Phaffia rhodozyma. Biotechnol. Tech. 4: 107–112.
  • Sheltzer J.M., A. Amon. 2011. The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends. Genet. 27: 446–453.
  • Sun N., S. Lee and K.B. Song. 2004. Characterization of a carotenoid-hyperproducing yeast mutant isolated by low-dose gamma irradiation. Int. J. Food. Microbiol. 94: 263–267.
  • Vazquez M., V. Santos and J.C. Parajo. 1999. Effect of the source on carotenoid profiles of Phaffia rhodozyma strains. J. Indust. Microbiol. Biotechnol. 19: 263–268.
  • Wolf A.M., S. Sadamitsu, H. Hiranuma, I. Ohsawa, K. Iio, A. Satou, M. Ishikura and S. Ohta. 2010. Astaxanthin protects mitochondraial redox state and functional integrity against oxidative stress. J. Nutr. Biochem. 21: 381–389.
  • Yamane Y.I., K. Higashid, Y. Nakashimada, T. Kakizono and N. Nishio. 1997. Astaxanthin production by Phaffia rhodozyma enhanced in fed-batch culture with glucose and ethanol feeding. Biotech. Lett. 19: 1109–1111.
  • Yuan J.P., J. Peng, K. Yin and J.H. Wang. 2011. Potential healthpromoting effects of astaxanthin: A high-value carotenoid mostly from microalgae. Mol. Nutr. Food. Res. 55: 150–165.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-f010dcdb-6c27-4f0d-a6ed-08a3b0429a2d
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.