PHYSICOCHEMICAL PROPERTIES OF GELS WITH CHITOSAN THAT PROTECT THE OESOPHAGEAL MUCOSA

• Autorzy: Katarzyna Małolepsza-Jarmołowska
• Języki publikacji: EN

Abstrakty

EN

The incidence of reflux disease increases with age, regardless of gender. This disease is diagnosed more often in highly developed countries. In addition to acidic reflux, the discharge of alkaline intestinal contents into the oesophagus is a major problem. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and hydroxypropylmethylcellulose on the properties of chitosan-containing gels. Preparations containing 4.0% hydroxypropylmethylcellulose showed the lowest pH. These gels could be used to treat advanced alkaline reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. The texture tests showed the effect of the hydroxypropylmethylcellulose concentration on the adhesion work of the tested gels.

Słowa kluczowe

EN

antiinflammatory drugs; gastroesophageal alkaline reflux; hydrophilic gels; oesophageal infections; oesophageal mucosa; physiological environment of gastroesophageal

• Czasopismo: Progress on Chemistry and Application of Chitin and its Derivatives
• Rocznik: 2022
• Tom: 27
• Strony: 175-182

Twórcy

autor

Katarzyna Małolepsza-Jarmołowska

• Wroclaw Medical University Department of Drug Form Technology, Faculty of Pharmacy The ‘Silesian Piasts’ Memorial Wroclaw Medical University,

Bibliografia

• [1] Katz PO, Gerson LB, Vela MF; (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 108, 308-328. DOI:10.1038/ajg.2012.444
• [2] Banks M; (2009) The modern investigation and management of gastro-oesophageal reflux disease (GERD). Clin Med 1, 18-27.
• [3] Raban M, Żak A, Litak J, Turska M, Grochowski C; (2017) Gastroesophageal reflux disease – unit description, diagnosis and treatment. J Educ Health Sport 7, 215-225.
• [4] Vakil N, van Zanten SV, Kahrilas T; (2006) The Montreal definition and classification of gastroesophageal reflux disease: a global evidence – based consensus. Am J Gastroenterol 101, 1900-1920.
• [5] Numans ME, Lau J, de Wit NJ, Bonis PA; (2004) Short-term treatment with protonpump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. Ann Internal Med 7, 518-527.
• [6] Singh M, Lee J, Gupta N, Gaddam S, Smith BK, Wani SB; (2013) Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial. Obesity 21, 284-290. DOI:10.1002/oby.20279
• [7] Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CAJ; (2006) Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 354, 2340-2348.
• [8] Ze EY, Kim BJ, Kang H, Kim JG; (2017) Abdominal visceral to subcutaneous adipose tissue ratio is associated with increased risk of erosive esophagitis. Dig Dis Sci 62, 1265-1271. DOI:10.1007/s10620-017-4467-4
• [9] Gao F, Gao Y, Chen X, Qian J, Zhang J; (2017) Comparison of oesophageal function tests between Chinese non-erosive reflux disease and reflux hypersensitivity patients. BMC Gastroenterol 67, 1-7. DOI:10.1186/s12876-017-0624-7
• [10] Małolepsza-Jarmołowska K; (2019) Influence of chitosan on the properties of gels protecting of the esophageal mucosa. Prog Chem Appl Chitin Deriv 24, 135-144. DOI:10.15259/PCACD.24.012

• Typ dokumentu: article