Synthesis and antimicrobial activity of {2-amino/2-methoxy}-4-(2’-n-butyl-4’-chloro-1’-H-imidazol-5’-yl)-6-aryl nicotinonitriles

• Autorzy: ,, , N. M. Dodia , D. M. Purohit
• Języki publikacji: EN

Abstrakty

EN

2-Amino-4-(2’-n-butyl-4’-chloro-1’-H-imidazol-5’-yl)-6-aryl nicotinonitriles. (2a-2j); 2-Methoxy-4-(2’-n-butyl-4’-chloro-1’-H-imidazol-5’-yl)-6-aryl nicotinonitriles. (3a-3j) have been synthesized. The products have been assayed for their antimicrobial activity against Gram +ve bacteria and Gram –ve bacteria and fungi. The products have been characterized by IR, 1HNMR, Mass Spectra and TLC.

Słowa kluczowe

EN

Amino Nicotinonitriles; Antimicrobial activity; Cyanopyridines; Methoxy Nicotinonitriles

• Wydawca: Scientific Publishing House „DARWIN”
• Czasopismo: World News of Natural Sciences
• Rocznik: 2022
• Tom: 43
• Strony: 76-82

Twórcy

autor

,,

• Industrial Chemistry Department, ITM Vocational University, Vadodara, Gujarat, India

autor

N. M. Dodia

• Zentiva Pharmaceutics Development Pvt. Ltd., Ankleshwar, Bharuch, Gujarat, India

autor

D. M. Purohit

• Chemistry Department, Shree M. and N. Virani Science College, Rajkot-360005, Gujarat, India

Bibliografia

• [1] E. Amir and M. Abdula. Synthesis of Cyanopyridines. Bioorganic Medicinal Chemistry, 14(13) (2006) 4341-4352
• [2] J. Marco and M. Carreiras. Synthesis and evaluation of cyanopyridines as Acetylcholinesterase inhibitors. Mini. Review Medicinal Chemistry, 3(6) (2003) 518-24
• [3] R. Ulrich and K. Thomas. Synthesis of novel cyanopyridine constraints as agonist receptor for treating cardiological or genitourinary disorders, inflammations, cancer and degenerative nerve diseases. Ger. Otten. DE, 10 238 (2003) 113
• [4] Gholap, K. Toti, F. Shirazi, R. Kumari and K. Srinivasana. Synthesis of analogues of cyanopyridine derivatives showing fungicidal activity. Bioorganic Medicinal Chemistry, 15(21) (2007) 6705-6715
• [5] P. Kathiria and D. Purohit. Cyanopyridines as Aurora-A selective kinase inhibitors. Organic Chemistry - An Indian Journal, 6(4) (2010) 262-266
• [6] R. Manikannan, S. Muthusubramanian, P. Yogeeswari and D. Sriram. Reported Cyanopyridine derivatives as anti-tubercular agents. Bioorganic Medicinal Chemistry Letters, 20(11) (2010) 3352-3355
• [7] A. Solankee, K. Kapadia, A. Ćirić, M. Soković, I. Doytchinova and A. Geronikaki. Synthesis and evaluation of cyanopyridines baring triazine molecule as potential anti-bacterial agents. European Journal of Medicinal Chemistry, 45(2) (2010) 510-518
• [8] F. Zhang, Y. Zhao, L. Sun, L. Ding, Y. Gu and P. Gong. Synthesis and evaluated aminocyanopyridines linked with indol as anti-tumor agents. European Journal of Medicinal Chemistry, 46(7) (2011) 3149-3157
• [9] M. Takhashi, K. Yabie, H. Kato, T. Kawamura, M. Matsumoto, M. H. Koizumi, A. Ono and A. Hirose. Reproduction and development toxicological examination of cyanopyridine scaffolds in mice. Reproductive Toxicology, 35 (2013) 7-16
• [10] Y. Mao, W. Zhu, J. Shen and J. Shen. Synthesis and evaluation of a series of new cyanopyridines as epidermal growth factor receptor TKI. Bioorganic Medicinal Chemistry, 21(11) (2013) 3090-3104
• [11] A. L. Barry; The Antimicrobial Susceptibility test, principle and practices. ELBS04th Edition, (1976) 180-193

• Typ dokumentu: article