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The aim of this paper was to formulate the composition of a bioadhesive film obtained based on acyclovir incorporated into natural bioadhesive polymers (chitosan and guar gum) in different quantitative ratios. To this end, the author developed a technology for preparing films containing various quantitative ratios of chitosan to guar gum: 1:0.25; 1:0.50; 1:0.75; 1:1; and 1.2:0.50. The formulations were used to prepare mucoadhesive films containing 2% acyclovir. The dressings were tested with respect to their physicochemical properties and subjected to dissolution testing. A comparative analysis of Fourier-transform infrared (FT-IR) spectra of pure polymers, acyclovir, and films containing polymers in different quantitative ratios was conducted. The quantitative ratio of chitosan to guar gum significantly impacted the mechanical properties of films: texture, elasticity, tensile strength, swelling, and blur time of the testes carriers. The 1:1 formulation showed the highest mechanical strength and flexibility. The dressing containing 1.2% chitosan and 0.5% guar gum had the longest blur time. An increase in the chitosan content in the formulation significantly affected the drug dissolution parameters, which makes it possible to achieve the desired effect of extended-release time. The FT-IR spectra excluded the formation of drug-polymer interactions. Changes in the quantitative ratios of chitosan and guar game in the carrier’s composition may impact the mechanical properties of the drug formulation and changes in the parameters of active substance release.
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106-115
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- Faculty of Pharmacy, Department of Pharmaceutical Technology, The ‘Silesian Piasts’ Memorial Medical University of Wroclaw, bozena.grimling@umed.wroc.pl
Bibliografia
- [1] Baiju RM, Peter E, Varghese NO, Sivaram R; (2017) Oral health and quality of life: current concepts. J Clin Diagn Res. 11, 21-26. DOI:10.7860/JCDR/2017/25866.10110
- [2] Santosh ABR, Muddana K; (2020) Viral infections of oral cavity. J Family Med Prim Care. 9, 36-42. DOI:10.4103/jfmpc.jfmpc_807_19
- [3] Mythri G, Kavitha K, Kumar M., Jagadeesh Singh SD; (2011) Novel mucoadhesive polymers – a review. J Appl Pharm Sci 1, 37-42.
- [4] Fong D, Hoemann CD, (2018) Chitosan immunomodulatory properties: perspectives on the impact of structural properties and dosage. Future Sci OA 4(1), FSO225. DOI:10.4155/fsoa-2017-0064
- [5] Ahsan SM, Thomas M, Reddy KK, Sooraparaju SG, Asthana A, Bhatnagar I; (2017) Chitosan as biomaterial in drug delivery and tissue engineering. Int J Biol Macromol 110, 97-109. DOI:10.1016/j.ijbiomac.2017.08.140
- [6] Singh M, Tiwary AK, Kaur G; (2010) Investigations on interpolymer complexes of cationic guar gum and xanthan gum for formulation of bioadhesive films. Res Pharm Sci 5, 79-87.
- [7] Nair AB, Al-ghannam AA, Al-Dhubiab BE, Hasan AA; (2017) Mucoadhesive film embedded with acyclovir loaded biopolymeric nanoparticles: in vitro studies. J Young Pharm 9, 100-105. DOI:10.5530/jyp.2017.9.19
- [8] Jacob S, Nair AB, Boddu SHS, Gorain B, Sreeharsha N, Shah J; (2021) An updated overview of the emerging role of patch and film-based buccal delivery systems.Pharmaceutics 13, 1206. DOI:10.3390/pharmaceutics13081206
- [9] Farmakopea Polska XI. Polska XI. Urząd Rejestracji Produktów Leczniczych, Wyrobów medycznych i Produktów Biobójczych.(2017), PTF, Warszawa, 491-494.
- [10] Vinklárková L., Masteiková R., Vetchý D., Doležel P., Bernatonienė J; (2015) Formulation of novel layered sodium carboxymethylcellulose film wound dressings with ibuprofen for alleviating wound pain. BioMed Res Int 2015, 892671, 1-11. DOI:10.1155/2015/892671
- [11] Momoha F, Boatenga J., Richardson S, Chowdhry B, Mitchel J; (2015) Development and functional characterization of alginate dressing as potential protein. Int J Biol Macromol 81, 137-150. DOI:10.1016/j.ijbiomac.2015.07.037
- [12] Batista RA, Espitia PJP, Vergne DMC, Vicente AA, Pereira PAC, Cerqueira MA, Teixeira JA, Jovanovic J, Severino P, Souto EB, Cardoso JC; (2020) Development and evaluation of superabsorbent hydrogels based on natural polymers. Polymers 12, 2173. DOI:10.3390/polym12102173
- [13] Dias RJ, Mali K., Ghorpade VS, Garje SB, Havaldar VD; (2010) In vitro absorption studies of acyclovir using natural permeation enhancers. Lat Am J Pharm 29, 1411-1418
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article
Bibliografia
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