INFLUENCE OF CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROTECTIVE PROPERTIES OF GELS WITH CHITOSAN FOR THE OESOPHAGEAL MUCOSA

• Autorzy: Katarzyna Małolepsza-Jarmołowska
• Języki publikacji: EN

Abstrakty

EN

Gastro-oesophageal reflux disease is a serious social problem that affects every sphere of life. The quality of life of people with this disease is reduced due to the presence of troublesome symptoms, which translates into reduced work efficiency and vitality. The major problem is acidic gastro-oesophageal reflux. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and carboxymethylcellulose sodium salt on the protective properties of prepared gels in the treatment of acid reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. Preparations containing 0.3% carboxymethylcellulose sodium salt showed the highest pH. The texture tests showed the effect of carboxymethylcellulose sodium salt concentration on the adhesion work of the tested gels. These gels could be used in the treatment of advanced acid reflux.

Słowa kluczowe

EN

antiinflammatory drugs; gastroesophageal acid reflux; hydrophilic gels; oesophageal infections; oesophageal mucosa; physiological environment of gastroesophageal

• Czasopismo: Progress on Chemistry and Application of Chitin and its Derivatives
• Rocznik: 2022
• Tom: 27
• Strony: 183-193

Twórcy

autor

Katarzyna Małolepsza-Jarmołowska

• Wroclaw Medical University Department of Drug Form Technology, Faculty of Pharmacy, The ‘Silesian Piasts’ Memorial Wroclaw Medical University,

Bibliografia

• [1] Singh M, Lee J, Gupta N, Gaddam S, Smith BK, Wani SB; (2013) Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial. Obesity 21, 284-290. DOI:10.1002/oby.20279
• [2] Banks M; (2009) The modern investigation and management of gastro-oesophageal reflux disease (GERD). Clin Med 1, 18-27.
• [3] Raban M, Żak A, Litak J, Turska M, Grochowski C; (2017) Gastroesophageal reflux disease – unit description, diagnosis and treatment. J Educ Health Sport 7, 215-225.
• [4] Katz PO, Gerson LB, Vela MF; (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 108, 308-328. DOI:10.1038/ajg.2012.444.
• [5] Numans ME, Lau J, de Wit NJ, Bonis PA; (2004) Short-term treatment with protonpump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. Ann Intern Med 7, 518-527.
• [6] Vakil N, van Zanten SV, Kahrilas T; (2006) The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 101, 1900-1920.
• [7] Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CAJ; (2006) Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 354, 2340-2348.
• [8] Ze EY, Kim BJ, Kang H, Kim JG; (2017) Abdominal visceral to subcutaneous adipose tissue ratio is associated with increased risk of erosive esophagitis. Dig Dis Sci 62, 1265-1271. DOI:10.1007/s10620-017-4467-4
• [9] Gao F, Gao Y, Chen X, Qian J, Zhang J; (2017) Comparison of oesophageal function tests between Chinese non-erosive reflux disease and reflux hypersensitivity patients. BMC Gastroenterol 67, 1-7. DOI:10.1186/s12876-017-0624-7
• [10] Małolepsza-Jarmołowska K; (2019) Influence of chitosan on the properties of gels protecting of the esophageal mucosa. Prog Chem Appl Chitin Deriv 24, 135-144. DOI:10.15259/PCACD.24.012

• Typ dokumentu: article