CHITOSAN GELS TO PREVENT REFLUX DISEASE

• Autorzy: Katarzyna Małolepsza-Jarmołowska
• Języki publikacji: EN

Abstrakty

EN

Reflux disease is one of the most frequently diagnosed conditions in developed countries. The problem is both the acidic content of the stomach and the alkaline content of the intestines. In each case, the oesophageal mucosa is destroyed. I analysed hydrogels that prevent irritation of the oesophageal mucosa. Specifically, I investigated the effect of chitosan and sodium alginate on the properties of gels protecting the oesophagus. Gels containing chitosan and 1.0% sodium alginate can be used to treat advanced alkaline reflux. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity, making it possible to neutralise acid reflux. Texture studies showed the influence of chitosan and sodium alginate on the adhesiveness of the tested gels.

Słowa kluczowe

EN

alkaline gastro-oesophageal reflux; anti-inflammatory drugs; hydrophilic gels; oesophageal infections; oesophageal mucosa; physiological gastro-oesophageal environment

• Czasopismo: Progress on Chemistry and Application of Chitin and its Derivatives
• Rocznik: 2023
• Tom: 28
• Strony: 103-110

Twórcy

autor

Katarzyna Małolepsza-Jarmołowska

• Department of Drug Form Technology, Faculty of Pharmacy, The ‘Silesian Piasts’ Memorial Wroclaw Medical University, Borowska 211A Str., 50–556 Wrocław, Poland,

Bibliografia

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• Typ dokumentu: article