ArticleOriginal scientific text
Title
Clinical aspects of protein glycation
Authors 1, 1, 1, 1, 2, 1,
Affiliations
- Chair of the Morphological Sciences, University of Rzeszów, Poland
- Department of Neurology, MSWiA Hospital, Rzeszów, Poland
Abstract
Introduction. Glycation is a post-translational modification of proteins that depends on the non-enzymatic linkage of a ketone
or aldehyde group of sugar with a free amino group of protein. Pathological effects of this process are observed in many
disease states under conditions of hyperglycemia, in diabetic complications, and neurodegenerative diseases such as multiple
sclerosis.
Aim. In this paper we present the characteristics of the glycation process, its consequences, as well as a review of current knowledge
about the role of glycation in multiple sclerosis.
Material and methods. The databases EBSCO, PubMed, ScienceDirect and SpringerLink were used to search the literature.
Analysis of the literature. Intermediate glycation products form a number of derivatives that contribute to oxidative stress
and structural changes in the proteins, including induction of aggregation or reduction of affinity for drug proteins. Glucose
products may contribute to neurodegenerative changes in patients with multiple sclerosis. Determination of protein glycation
products can be successfully used to evaluate the course of multiple sclerosis as a diagnostic marker.
Keywords
AGEs, glycation, advanced glycation end products, multiple sclerosis