Immunoregulation of lymphoproliferation in vitro by monocytes and their subpopulations. II. Phenotypic changes of T cells in cultures activated with antigen and mitogen

• Autorzy: Janusz Pryjma , Danuta Kowalczyk , Irena Ruggiero , Marek Zembala
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to analyze phenotypes of T cells activated by mitogen (PWM) and antigen (PPD) in the presence of FcR+ or FcR- monocytes. It was found that CD4+ and CD8+ lymphocytes are preferentially acitvated in the presence of different subpopulations. Expression of HLA-DR and CD25 on CD4+ lymphocytes was greater in cultures activated in the presence of FcR-. CD8+ lymphocytes were more efficiently activated (exprression of HLA-DR) when FcR+ monocytes were added to culture. In the presence of FcR+ monocytes an increased expression of CD45RA antigen on CD4+ cells was also observed. These data support our previous functional studies which showed that "suppressor" T cells of CD8+ phenotype are activated in the presence of FcR+ monocytes.

Słowa kluczowe

EN

ANTIGEN; IMMUNOREGULATION; LYMPHOPROLIFERATION; MITOGEN; MONOCYTE; T CELL

• Czasopismo: Archivum Immunologiae et Therapiae Experimentalis
• Rocznik: 1992
• Tom: 40
• Numer: 2
• Strony: 139-143

Twórcy

autor

Janusz Pryjma

autor

Danuta Kowalczyk

autor

Irena Ruggiero

autor

Marek Zembala

• Typ dokumentu: article