Czasopismo
Tytuł artykułu
Wybrane pełne teksty z tego czasopisma
Warianty tytułu
Języki publikacji
Abstrakty
Alzheimer's disease (AD) is a neurodegenerative disorder with a complex etiology and pathogenesis. Mutations in presenilin 1 gene (PSEN1), located on chromosome 14, more rarely in amyloid-beta protein precursor (APP) on chromosome 21, and presenilin 2 genes (PSEN2) on chromosome 1, underlie the pathogenesis of most cases of familial early onset of AD (EOAD). The genetics of late-onset AD (LOAD) have been more enigmatic and the only confirmed risk factor for LOAD remains the apolipoprotein E4 allele (ApoE4) on chromosome 19. In this review, we discuss the genetics of AD with a focus on the role of the APP and presenilins.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Numer
Strony
19-31
Opis fizyczny
Twórcy
Bibliografia
Typ dokumentu
REVIEW
Bibliografia
C. Zekanowski, Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, 4 Trojdena St., 02-109 Warsaw, Poland
Identyfikatory
Identyfikator YADDA
bwmeta1.element.element-from-psjc-dd342088-8390-31ec-959b-956f8bfe93fa