Agonists and antagonists of adenosine receptors and morphine withdrawal syndrome in rats

• Autorzy: Eliza Michalska , Danuta Malec
• Języki publikacji: EN

Abstrakty

EN

The compounds activating adenosine system alleviated morphine withdrawal syndrome (the number of escape attempts and body shakes) in rats. Body shakes were decreased mostly by N-ethylcarboxamidoadenosine, cyclohexyladenosine, dipyridamole and 2-chloroadenosine, while R-phenylisopropyladenosine very strongly decreased the number of escape attempts. Adenosine receptor antagonists (caffeine and theophylline) increased the number of escape attempts in morphine-dependent rats. Caffeine (10 mg/kg), administered preventively, antagonized the ingibitory effects of adenosine analogs. These results suggest the existence of relation between opioid receptors and the adenosine system.

Słowa kluczowe

EN

ADENOSINE RECEPTOR; ADENOSINE SYSTEM; MORPHINE; OPIOID RECEPTOR; RAT

• Czasopismo: Polish Journal of Pharmacology
• Rocznik: 1993
• Tom: 45
• Numer: 1
• Strony: 1-9

Twórcy

autor

Eliza Michalska

autor

Danuta Malec

• Typ dokumentu: article