In vitro cytostatic activity of some amino acid 4-N-substituted cytosines

• Autorzy: Boguslaw Hladon , Anna Sloderbach , Przemyslaw Radosh , Jaroslaw Spychala , Krzysztof Golankiewicz
• Języki publikacji: EN

Abstrakty

EN

Cytotoxicity of 22 amino acid 4-N-substitued cytosine derivatives was studied on KB and HeLa human tissue cultures. The secondary modification of tryptamine substituent seems to be a determining factor of the cytotoxic activity of 4-N-pyrimidinyl amino acids. The activity of the investigated compounds was inversely dependent on their solubility limited by the results of the solubility-activity relationship analysis.

Słowa kluczowe

EN

AMINO ACID; CYTOSTATIC ACTIVITY

• Czasopismo: Archivum Immunologiae et Therapiae Experimentalis
• Rocznik: 1992
• Tom: 40
• Numer: 2
• Strony: 145-150

Twórcy

autor

Boguslaw Hladon

autor

Anna Sloderbach

autor

Przemyslaw Radosh

autor

Jaroslaw Spychala

autor

Krzysztof Golankiewicz

• Typ dokumentu: article