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The work was carried out to estimate satellite association (SA) frequency of acrocentric chromosomes in male and female persons with goiter at a normal, increased and decreased concentrations of thyroid hormones with relation to meiotic or mitotic nondisjunction.Satelite associations were estimated on the methaphase plates obtained through macroculture of peripheral blood limphocytes.The concentration of triiodothyronine (T3) and thyroxine (T4) was determined by the method of radioimmunological analysis (RIA).
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