Warianty tytułu
Języki publikacji
Abstrakty
Using fluorescence in situ hybridization (FISH) to somatic nuclear halos from transgenic rabbits WAP:6xHishGH, we present evidence for stability of transgenesis at the chromatin level. FISH performed on fibroblasts from a homozygous individual showed 2 independent loops from both chromosomes of pair 7. On a heterozygous individual, FISH detected a single loop. According to the concept of chromatin loops and their influence on gene expression, this shows that the human growth hormone transgene, which was actively expressed in mammary gland under the influence of the tissue-specific promoter, was inactive in examined skin fibroblasts.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Numer
Strony
247-249
Opis fizyczny
Twórcy
Bibliografia
Typ dokumentu
ARTICLE
Bibliografia
E. Michalak, Department of Biochemistry and Biotechnology, Agricultural University, Wolynska 35, 60?637 Poznan, Poland
Identyfikatory
Identyfikator YADDA
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